ArticleBiomedical microdevices2009
Integrated microfluidic devices for combinatorial cell-based assays.
Article in Biomedical microdevices, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Rapid Prototyping of Compartmentalized 3D Microfluidic Devices for Organotypic Cell Culture.Micromachines · 2026Article
- Review
- A brief overview of passive microvalves in microfluidics: Mechanism, manufacturing, and applications.Biomicrofluidics · 2024Review
- Integrated-gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease.Communications biology · 2023Article
- Microfluidic Wound-Healing Assay for ECM and Microenvironment Properties on Microglia BV2 Cells Migration.Biosensors · 2023Article
- Recent advances of integrated microfluidic suspension cell culture system.Engineering biology · 2021Review
- What can microfluidics do for human microbiome research?Biomicrofluidics · 2020Article
- Organ-on-a-chip engineering: Toward bridging the gap between lab and industry.Biomicrofluidics · 2020Review
- Single-Layered Microfluidic Network-Based Combinatorial Dilution for Standard Simplex Lattice Design.Micromachines · 2018Article
- Transfection in perfused microfluidic cell culture devices: A case study.Process biochemistry (Barking, London, England) · 2017Article
- Centrifugal microfluidics for sorting immune cells from whole blood.Sensors and actuators. B, Chemical · 2017Article
- Biocompatibility of fluids for multiphase drops-in-drops microfluidics.Biomedical microdevices · 2016Article
- Accelerated Biofluid Filling in Complex Microfluidic Networks by Vacuum-Pressure Accelerated Movement (V-PAM).Small (Weinheim an der Bergstrasse, Germany) · 2016Article
- Review
- Rapid, automated, parallel quantitative immunoassays using highly integrated microfluidics and AlphaLISA.Scientific reports · 2015Article
- The role of engineering approaches in analysing cancer invasion and metastasis.Nature reviews. Cancer · 2013Review
- Microwell perfusion array for high-throughput, long-term imaging of clonal growth.Biomicrofluidics · 2011Article
- Scaffold fabrication in a perfusion culture microchamber array chip by O(2) plasma bonding of poly(dimethylsiloxane) protected by a physical mask.Biomicrofluidics · 2011Article
- A beta-camera integrated with a microfluidic chip for radioassays based on real-time imaging of glycolysis in small cell populations.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
The development of miniaturized cell culture platforms for performing parallel cultures and combinatorial assays is important in cell biology from the single-cell level to the system level. In this paper we developed an integrated microfluidic cell-culture platform, Cell-microChip (Cell-microChip), for parallel analyses of the effects of microenvironmental cues (i.e., culture scaffolds) on different mammalian cells and their cellular responses to external stimuli. As a model study, we demonstrated the ability of culturing and assaying several mammalian cells, such as NIH 3T3 fibroblast, B16 melanoma and HeLa cell lines, in a parallel way. For functional assays, first we tested drug-induced apoptotic responses from different cell lines. As a second functional assay, we performed "on-chip" transfection of a reporter gene encoding an enhanced green fluorescent protein (EGFP) followed by live-cell imaging of transcriptional activation of cyclooxygenase 2 (Cox-2) expression. Collectively, our Cell-microChip approach demonstrated the capability to carry out parallel operations and the potential to further integrate advanced functions and applications in the broader space of combinatorial chemistry and biology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.