ArticleVirus genes2009
Transcriptional suppression of IE180 and TK promoters by the EP0 of pseudorabies virus strains Ea and Fa.
Article in Virus genes, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Review
- Comparative proteomic analysis of PK-15 cells infected with wild-type strain and its EP0 gene-deleted mutant strain of pseudorabies virus.Journal of veterinary science · 2024Article
- Application of CRISPR/Cas9 for Rapid Genome Editing of Pseudorabies Virus and Bovine Herpesvirus-1.Viruses · 2024Article
- Advances in the immunoescape mechanisms exploited by alphaherpesviruses.Frontiers in microbiology · 2024Review
- Resveratrol Inhibits Pseudorabies Virus Replication by Targeting IE180 Protein.Frontiers in microbiology · 2022Article
- Article
- Identification of nuclear and nucleolar localization signals of pseudorabies virus (PRV) early protein UL54 reveals that its nuclear targeting is required for efficient production of PRV.Journal of virology · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In our transient expression assays, the IE180 and TK promoters were markedly suppressed by the EP0 of the pseudorabies virus strains Ea and Fa (EP0/Ea, EP0/Fa). This is in contrast with the transactivating activity of EP0 from strain YS-81 (EP0/YS-81) in previous studies. Amino acid sequence alignment revealed several mutations in both EP0/Ea and EP0/Fa compared with EP0/YS-81. Most remarkable is a two-amino acid substitution next to the RING finger domain which was considered to be important for the transactivating activity of EP0 in previous studies. To address the effect of the two-amino acid substitution on the function of EP0, reverse mutants of EP0/Ea and EP0/Fa were generated. The subsequent expression assays indicated that this substitution was at least in part responsible for the effect on the regulatory activity of EP0. Our data suggested that EP0 may regulate the expression of the same genes in different pseudorabies virus strains differently.
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Registered trials
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