ArticleMolecular and cellular biochemistry2009
Hypertriglyceridemia: phenomics and genomics.
Article in Molecular and cellular biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 59 citations in OpenAlex.
- Comparative efficacy and safety of olezarsen versus volanesorsen for familial chylomicronemia syndrome: a matching-adjusted indirect comparison.Journal of comparative effectiveness research · 2026Trial
- Germline variant analysis from a cohort of patients with severe hypertriglyceridemia in Brazil.Molecular genetics and metabolism reports · 2024Article
- Clinical characterization and mutation spectrum of patients with hypertriglyceridemia in a German outpatient clinic.Journal of lipid research · 2024Article
- Dyslipidemia in diffuse large B-cell lymphoma based on the genetic subtypes: a single-center study of 259 Chinese patients.Frontiers in oncology · 2023Article
- A Modern Approach to Dyslipidemia.Endocrine reviews · 2022Article
- Causes, clinical findings and therapeutic options in chylomicronemia syndrome, a special form of hypertriglyceridemia.Lipids in health and disease · 2022Review
- Rare novel LPL mutations are associated with neonatal onset lipoprotein lipase (LPL) deficiency in two cases.BMC pediatrics · 2021Article
- The contribution of rare genetic variants to the pathogenesis of polycystic ovary syndrome.Current opinion in endocrine and metabolic research · 2020Article
- Genetics of Hypertriglyceridemia.Frontiers in endocrinology · 2020Review
- A NovelThe application of clinical genetics · 2020Article
- How Genomics Is Personalizing the Management of Dyslipidemia and Cardiovascular Disease Prevention.Current cardiology reports · 2018Review
- Lipase maturation factor 1 affects redox homeostasis in the endoplasmic reticulum.The EMBO journal · 2018Article
- Rare LPL gene missense mutation in an infant with hypertriglyceridemia.Journal of clinical laboratory analysis · 2018Article
- Apolipoprotein C-II: New findings related to genetics, biochemistry, and role in triglyceride metabolism.Atherosclerosis · 2017Review
- Article
- Frequency of rare mutations and common genetic variations in severe hypertriglyceridemia in the general population of Spain.Lipids in health and disease · 2016Article
- Chylomicronaemia--current diagnosis and future therapies.Nature reviews. Endocrinology · 2015Review
- Purification, cellular levels, and functional domains of lipase maturation factor 1.Biochemical and biophysical research communications · 2014Article
- Article
- APOA5 Q97X mutation identified through homozygosity mapping causes severe hypertriglyceridemia in a Chilean consanguineous family.BMC medical genetics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertriglyceridemia is a common complex metabolic trait that is associated with increased atherosclerosis risk, presence of the metabolic syndrome and, with extreme elevation, increased risk of pancreatitis. Hierarchical cluster analysis using clinical and biochemical features of the Frederickson hyperlipoproteinemia types can generate hypotheses for molecular genetic studies. High throughput resequencing of individuals at the extremes of plasma triglyceride concentration has shown that both rare genetic variants with large effects and common genetic variants with moderate effects explain a relatively large proportion of variation. Very recent progress using high-density sets of genome-wide markers have identified additional genetic determinants of plasma triglyceride concentrations, albeit within largely normolipidemic subjects and with small effect sizes. Phenomic evaluation of patients with hypertriglyceridemia might help to clarify genotype-phenotype correlations and responses to interventions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.