Evidence map›Paper›PMID 19130041›Full record

Trial reportDiabetologia2009

Anti-inflammatory effect of lifestyle changes in the Finnish Diabetes Prevention Study.

C Herder, M Peltonen, W Koenig, K Sütfels, J Lindström, S Martin, P Ilanne-Parikka, J G Eriksson, S Aunola, S Keinänen-Kiukaanniemi and 5 more

Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Diabetologia, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 4 pooled it
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 4 syntheses or guidelines pooled it, 161 citations in OpenAlex.

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  9. Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2014
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

C HerderInstitute for Clinical Diabetology, German Diabetes Centre, Leibniz Centre at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
M Peltonen
W Koenig
K Sütfels
J Lindström
S Martin
P Ilanne-Parikka
J G Eriksson
S Aunola
S Keinänen-Kiukaanniemi
T T Valle
M Uusitupa
H Kolb
J Tuomilehto
Finnish Diabetes Prevention Study Group
Heinrich Heine University Düsseldorf · DEUniversity of Helsinki · FIDeutsches Diabetes-Zentrum e.V. · DEFinnish Diabetes Association · FIUniversität Ulm · DEUniversity of Eastern Finland · FIUniversity of Oulu · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisSubclinical inflammation confers an increased risk of type 2 diabetes, cardiovascular disease, neurodegenerative disorders and other age-related chronic diseases. Physical activity and diet can attenuate systemic immune activation, but it is not known which individual components of a comprehensive lifestyle intervention are most effective in targeting subclinical inflammation.

methodsWe used data from the baseline examination and the 1 year follow-up of a subsample of 406 of 522 participants of the Finnish Diabetes Prevention Study (DPS) to estimate the effect of individual components of lifestyle intervention on C-reactive protein (CRP) and IL-6 levels, which represent the best characterised proinflammatory risk factors for type 2 diabetes. Changes in metabolic markers, dietary patterns and exercise were analysed to determine which were most strongly associated with the anti-inflammatory effect of lifestyle changes.

resultsLifestyle intervention reduced circulating levels of CRP (p < 0.001) and IL-6 (p = 0.060). Increases in fibre intake and moderate to vigorous leisure time physical activity (LTPA), but not total LTPA, predicted decreases in CRP and/or IL-6 and remained associated even after adjustment for baseline BMI or changes in BMI during the first year of the study. Changes in carbohydrate or fat intake were either weakly or not linked to reductions in CRP and IL-6. CONCLUSIONS/

interpretationThe present study assessed the individual effects of dietary and physical activity measures on low-grade inflammation in individuals at high cardiometabolic risk. Our results underline the importance of moderate to vigorous LTPA and a diet rich in natural fibre, and this should be emphasised in lifestyle recommendations.

Indexed as

Life StyleBlood GlucoseBlood PressureBody Mass IndexBody WeightCalorimetryC-Reactive ProteinDiabetes MellitusDietary FiberEnergy IntakeExerciseFinlandGlucose IntoleranceHumansInflammationInsulinBlood GlucoseC-Reactive ProteinDietary FiberInsulin

Identifiers

PMID19130041
OpenAlexW2070156280

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.