ReviewResults and problems in cell differentiation2010
Potential triggers of MS.
Review in Results and problems in cell differentiation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Investigating the eukaryotic host-like SLiMs in microbial mimitopes and their potential as novel drug targets for treating autoimmune diseases.Frontiers in microbiology · 2022Article
- Investigating the disordered regions (MoRFs, SLiMs and LCRs) and functions of mimicry proteins/peptides in silico.PloS one · 2022Article
- Differential transcriptomic changes in the central nervous system and urinary bladders of mice infected with a coronavirus.PloS one · 2022Article
- Peripheral viral challenge increases c-fos level in cerebral neurons.Metabolic brain disease · 2021Article
- Viral mouse models used to study multiple sclerosis: past and present.Archives of virology · 2021Review
- COVID-19: dealing with a potential risk factor for chronic neurological disorders.Journal of neurology · 2021Review
- PART 2: Mouse models for multiple sclerosis research.Neurourology and urodynamics · 2021Review
- Neuronal CXCL10/CXCR3 Axis Mediates the Induction of Cerebral Hyperexcitability by Peripheral Viral Challenge.Frontiers in neuroscience · 2020Article
- Article
- Peripheral viral challenge exacerbates experimental autoimmune encephalomyelitis.Metabolic brain disease · 2019Article
- An evaluation of HHV-6 as an etiologic agent in Hodgkin lymphoma and brain cancer using IARC criteria for oncogenicity.Infectious agents and cancer · 2019Review
- Innate Immune Responses and Viral-Induced Neurologic Disease.Journal of clinical medicine · 2018Review
- Signaling pathways and therapeutic perspectives related to environmental factors associated with multiple sclerosis.Journal of neuroscience research · 2018Review
- Herpesvirus trigger accelerates neuroinflammation in a nonhuman primate model of multiple sclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Theiler's murine encephalomyelitis virus infection of SJL/J and C57BL/6J mice: Models for multiple sclerosis and epilepsy.Journal of neuroimmunology · 2017Review
- The MHC locus and genetic susceptibility to autoimmune and infectious diseases.Genome biology · 2017Review
- HTLV-1, Immune Response and Autoimmunity.Viruses · 2015Review
- Multiple sclerosis: autoimmunity and viruses.Current opinion in rheumatology · 2013Review
- Epstein-Barr virus in systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis—association and causation.Viruses · 2012Review
- Possible role of interleukin-17 in a prime/challenge model of multiple sclerosis.Journal of neurovirology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
MS is an immune mediated disease of the central nervous system (CNS) characterized by demyelination, axonal damage and neurologic disability. The primary cause of this CNS disease remains elusive. Here we will address our current understanding of the role of viruses as potential environmental triggers for MS. Virus infections can act peripherally (outside the CNS) or within the CNS. The association of viral infections with demyelinating disease, in both animals and humans, will be discussed, as will the potential contributions of peripheral infection with Torque Teno virus, infection outside of and/or within the CNS with Epstein-Barr virus and infection within the CNS with Human Herpesvirus 6 to MS. An experimental animal model, Theiler's murine encephalomyelitis virus infection of susceptible strains of mice is an example of viral infections of the CNS as a prerequisite for demyelination. Finally, the proposition that multiple virus infections are required, which first prime the immune system and then trigger the disease, as a model where infections outside of the CNS lead to inflammatory changes within the CNS, for the development of a MS-like disease is explored.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.