ArticleFrontiers in computational neuroscience2008
Modeling thalamocortical cell: impact of ca channel distribution and cell geometry on firing pattern.
Article in Frontiers in computational neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Cell-type-specific integration of feedforward and feedback synaptic inputs in the posterior parietal cortex.Neuron · 2022Article
- Dual function of thalamic low-vigilance state oscillations: rhythm-regulation and plasticity.Nature reviews. Neuroscience · 2018Review
- Action potential initiation in a two-compartment model of pyramidal neuron mediated by dendritic CaScientific reports · 2017Article
- The Global Spike: Conserved Dendritic Properties Enable Unique Ca2+ Spike Generation in Low-Threshold Spiking Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The interplay of seven subthreshold conductances controls the resting membrane potential and the oscillatory behavior of thalamocortical neurons.Journal of neurophysiology · 2014Article
- Asymmetry in signal propagation between the soma and dendrites plays a key role in determining dendritic excitability in motoneurons.PloS one · 2014Article
- The subcellular distribution of T-type Ca2+ channels in interneurons of the lateral geniculate nucleus.PloS one · 2014Article
- Regulation of AMPA and NMDA receptor-mediated EPSPs in dendritic trees of thalamocortical cells.Journal of neurophysiology · 2013Article
- A multi-compartment model for interneurons in the dorsal lateral geniculate nucleus.PLoS computational biology · 2011Article
- Minimal alterations in T-type calcium channel gating markedly modify physiological firing dynamics.The Journal of physiology · 2011Article
- Consequences of non-uniform active currents in dendrites.Frontiers in neuroscience · 2009Article
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3 authors.
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Abstract
The influence of calcium channel distribution and geometry of the thalamocortical cell upon its tonic firing and the low threshold spike (LTS) generation was studied in a 3-compartment model, which represents soma, proximal and distal dendrites as well as in multi-compartment model using the morphology of a real reconstructed neuron. Using an uniform distribution of Ca(2+) channels, we determined the minimal number of low threshold voltage-activated calcium channels and their permeability required for the onset of LTS in response to a hyperpolarizing current pulse. In the 3-compartment model, we found that the channel distribution influences the firing pattern only in the range of 3% below the threshold value of total T-channel density. In the multi-compartmental model, the LTS could be generated by only 64% of unequally distributed T-channels compared to the minimal number of equally distributed T-channels. For a given channel density and injected current, the tonic firing frequency was found to be inversely proportional to the size of the cell. However, when the Ca(2+) channel density was elevated in soma or proximal dendrites, then the amplitude of LTS response and burst spike frequencies were determined by the ratio of total to threshold number of T-channels in the cell for a specific geometry.
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