Gamma-secretase inhibitors: Notch so bad.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

19 citing papers in PubMed.

1. Advances in Tricyclic Compounds for the Treatment of Alzheimer's Disease.ChemMedChem · 2026
   Review
2. Innate and adaptive immune abnormalities underlying autoimmune diseases: the genetic connections.Science China. Life sciences · 2023
   Review
3. JAK/BCL2 inhibition acts synergistically with LSD1 inhibitors to selectively target ETP-ALL.Leukemia · 2022
   Article
4. Identification and targeting of a HES1-YAP1-CDKN1C functional interaction in fusion-negative rhabdomyosarcoma.Molecular oncology · 2022
   Article
5. Calcitonin Gene-Related Peptide Attenuates Hyperoxia-Induced Oxidative Damage in Alveolar Epithelial Type II Cells Through Regulating Viability and Transdifferentiation.Inflammation · 2022
   Article
6. Therapeutic and diagnostic targeting of fibrosis in metabolic, proliferative and viral disorders.Advanced drug delivery reviews · 2021
   Review
7. A Review on Notch Signaling and Colorectal Cancer.Cells · 2020
   Review
8. The Role of Notch and Wnt Signaling in MSC Communication in Normal and Leukemic Bone Marrow Niche.Frontiers in cell and developmental biology · 2020
   Review
9. Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration.The Journal of clinical investigation · 2016
   Article
10. Cancer Stem Cell and Gastrointestinal Cancer: Current Status, Targeted Therapy and Future Implications.Biochemistry & pharmacology : open access · 2016
    Article
11. Other targeted drugs in melanoma.Annals of translational medicine · 2015
    Review
12. Induced transcription and stability of CELF2 mRNA drives widespread alternative splicing during T-cell signaling.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
13. A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP.PloS one · 2015
    Article
14. Stem cells in gastrointestinal cancers: The road less travelled.World journal of stem cells · 2014
    Review
15. Gastric cancer stem cells: therapeutic targets.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2014
    Review
16. The role of Irf6 in tooth epithelial invagination.Developmental biology · 2012
    Article
17. Epigenetic regulation of Delta-Like1 controls Notch1 activation in gastric cancer.Oncotarget · 2011
    Article
18. Alterations of the Notch pathway in lung cancer.Proceedings of the National Academy of Sciences of the United States of America · 2009
    Article
19. Stem cells and solid cancers.Virchows Archiv : an international journal of pathology · 2009
    Review

Corrections and comments

• Comment on
  Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia.2009

Authors and funding

1 author.

Funding

Abstract

PubMed holds no abstract for this paper.

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