ArticleDementia and geriatric cognitive disorders2009
Serum lipids are related to Alzheimer's pathology in nursing home residents.
Article in Dementia and geriatric cognitive disorders, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Low-Density Lipoprotein Cholesterol and Alzheimer's Disease: A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2020Pooled it
- Digital neuropsychological measures by defense automated neurocognitive assessment: reference values and clinical correlates.Frontiers in neurology · 2024Article
- Roles of Heme Oxygenase-1 in Neuroinflammation and Brain Disorders.Antioxidants (Basel, Switzerland) · 2022Review
- Article
- Genetic Predisposition to Low-Density Lipoprotein Cholesterol May Increase Risks of Both Individual and Familial Alzheimer's Disease.Frontiers in medicine · 2021Article
- Association of Hypercholesterolemia with Alzheimer's Disease Pathology and Cerebral Amyloid Angiopathy.Journal of Alzheimer's disease : JAD · 2020Article
- Sex-specific nonlinear associations between serum lipids and different domains of cognitive function in middle to older age individuals.Metabolic brain disease · 2017Article
- Association between Cholesterol Exposure and Neuropathological Findings: The ACT Study.Journal of Alzheimer's disease : JAD · 2017Article
- Dietary cholesterol concentration affects synaptic plasticity and dendrite spine morphology of rabbit hippocampal neurons.Brain research · 2015Article
- Alzheimer's disease: Unique markers for diagnosis & new treatment modalities.The Indian journal of medical research · 2015Review
- Effective components of Chinese herbs reduce central nervous system function decline induced by iron overload.Neural regeneration research · 2015Article
- Disease risk factors identified through shared genetic architecture and electronic medical records.Science translational medicine · 2014Article
- Vascular disease and dementias: paradigm shifts to drive research in new directions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2013Review
- Mild hypercholesterolemia, normal plasma triglycerides, and normal glucose levels across dementia staging in Alzheimer's disease: a clinical setting-based retrospective study.American journal of Alzheimer's disease and other dementias · 2011Article
- Cholesterol and LDL relate to neuritic plaques and to APOE4 presence but not to neurofibrillary tangles.Current Alzheimer research · 2011Article
- The vascular contribution to Alzheimer's disease.Clinical science (London, England : 1979) · 2010Review
- The effects of cholesterol on learning and memory.Neuroscience and biobehavioral reviews · 2010Review
- Vascular risk factors: imaging and neuropathologic correlates.Journal of Alzheimer's disease : JAD · 2010Review
- The effects of cardiovascular risk factors on cognitive compromise.Dialogues in clinical neuroscience · 2009Review
- Blood lipids as accessible biomarkers for early dementia risk screening: Bridging diagnostic gaps in resource-limited settings.Journal of Alzheimer's disease reportsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundStudies of associations between serum lipids and Alzheimer's disease (AD) or other dementias in the elderly show conflicting results, perhaps due to misclassification of the various dementias.
methodsFor 358 nursing home residents, serum lipids were studied at admission and diagnoses established at autopsy. We used defined neuropathological criteria to distinguish the presence of AD and to avoid errors of clinical dementia assessment.
resultsResidents with any AD pathology, as compared to those without AD pathology, had higher mean serum total cholesterol (TC; 200.4 vs. 185.9 mg/dl; p = 0.02) and higher mean low-density lipoprotein cholesterol (LDL; 124.5 vs. 111.5 mg/dl; p = 0.03). Further, mean TC, LDL and high-density lipoprotein cholesterol levels all increased progressively with increasing pathological certainty of AD (p for trend = 0.001, 0.02 and 0.02).
conclusionsTC and LDL were significantly related to pathologically defined AD. If serum lipids have a role in the pathogenesis of AD, interventions may modify the course of disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.