ArticleGenome research2009
The genomic architecture of segmental duplications and associated copy number variants in dogs.
Article in Genome research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.
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Who cites it
101 citing papers in PubMed.
- Genome wide landscaping of copy number variations for horse inter-breed variability.Animal biotechnology · 2025Article
- Duplications and Retrogenes Are Numerous and Widespread in Modern Canine Genomic Assemblies.Genome biology and evolution · 2024Article
- Genomic structural variation: A complex but important driver of human evolution.American journal of biological anthropology · 2023Review
- DNA sequence features underlying large-scale duplications and deletions in human.Journal of applied genetics · 2022Article
- Population differentiated copy number variation of Bos taurus, Bos indicus and their African hybrids.BMC genomics · 2021Article
- A novel canine reference genome resolves genomic architecture and uncovers transcript complexity.Communications biology · 2021Article
- Genomic Copy Number Variation Study of Nine Macaca Species Provides New Insights into Their Genetic Divergence, Adaptation, and Biomedical Application.Genome biology and evolution · 2020Article
- Whole genome resequencing of the Iranian native dogs and wolves to unravel variome during dog domestication.BMC genomics · 2020Article
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- Identification of copy number variations using high density whole-genome SNP markers in Chinese Dongxiang spotted pigs.Asian-Australasian journal of animal sciences · 2019Article
- Computational detection and experimental validation of segmental duplications and associated copy number variations in water buffalo ( Bubalus bubalis ).Functional & integrative genomics · 2019Article
- A Genome-Wide Detection of Copy Number Variations Using SNP Genotyping Arrays in Braque Français Type Pyrénées Dogs.Animals : an open access journal from MDPI · 2019Article
- Comparison of village dog and wolf genomes highlights the role of the neural crest in dog domestication.BMC biology · 2018Article
- Genetic Diversity of Seven Cattle Breeds Inferred Using Copy Number Variations.Frontiers in genetics · 2018Article
- Similar genomic proportions of copy number variation within gray wolves and modern dog breeds inferred from whole genome sequencing.BMC genomics · 2017Article
- Genome-wide analysis reveals differential selection involved with copy number variation in diverse Chinese Cattle.Scientific reports · 2017Article
- Segmental duplications: evolution and impact among the current Lepidoptera genomes.BMC evolutionary biology · 2017Article
- Characterization of genome-wide segmental duplications reveals a common genomic feature of association with immunity among domestic animals.BMC genomics · 2017Article
- CNV discovery for milk composition traits in dairy cattle using whole genome resequencing.BMC genomics · 2017Article
41 more citing papers are in PubMed but not listed here.
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6 authors.
Funding
Abstract
Structural variation is an important and abundant source of genetic and phenotypic variation. Here we describe the first systematic and genome-wide analysis of segmental duplications and associated copy number variants (CNVs) in the modern domesticated dog, Canis familiaris, which exhibits considerable morphological, physiological, and behavioral variation. Through computational analyses of the publicly available canine reference sequence, we estimate that segmental duplications comprise approximately 4.21% of the canine genome. Segmental duplications overlap 841 genes and are significantly enriched for specific biological functions such as immunity and defense and KRAB box transcription factors. We designed high-density tiling arrays spanning all predicted segmental duplications and performed aCGH in a panel of 17 breeds and a gray wolf. In total, we identified 3583 CNVs, approximately 68% of which were found in two or more samples that map to 678 unique regions. CNVs span 429 genes that are involved in a wide variety of biological processes such as olfaction, immunity, and gene regulation. Our results provide insight into mechanisms of canine genome evolution and generate a valuable resource for future evolutionary and phenotypic studies.
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