ArticleJournal of virology2009
Borna disease virus requires cholesterol in both cellular membrane and viral envelope for efficient cell entry.
Article in Journal of virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Virion-Associated Cholesterol Regulates the Infection of Human Parainfluenza Virus Type 3.Viruses · 2019Article
- Effects of host cell sterol composition upon internalization ofThe Journal of biological chemistry · 2018Article
- Cholesterol-rich lipid rafts are required for release of infectious human respiratory syncytial virus particles.Virology · 2012Article
- Borna disease virus infection perturbs energy metabolites and amino acids in cultured human oligodendroglia cells.PloS one · 2012Article
- A synthetic cannabinoid agonist promotes oligodendrogliogenesis during viral encephalitis in rats.Experimental neurology · 2010Article
- Identification of host factors involved in borna disease virus cell entry through a small interfering RNA functional genetic screen.Journal of virology · 2010Article
- Characterization of Lassa virus glycoprotein oligomerization and influence of cholesterol on virus replication.Journal of virology · 2010Article
- Molecular chaperone BiP interacts with Borna disease virus glycoprotein at the cell surface.Journal of virology · 2009Article
- Cell entry of Borna disease virus follows a clathrin-mediated endocytosis pathway that requires Rab5 and microtubules.Journal of virology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Borna disease virus (BDV), the prototypic member of the family Bornaviridae within the order Mononegavirales, provides an important model for the investigation of viral persistence within the central nervous system (CNS) and of associated brain disorders. BDV is highly neurotropic and enters its target cell via receptor-mediated endocytosis, a process mediated by the virus surface glycoprotein (G), but the cellular factors and pathways determining BDV cell tropism within the CNS remain mostly unknown. Cholesterol has been shown to influence viral infections via its effects on different viral processes, including replication, budding, and cell entry. In this work, we show that cell entry, but not replication and gene expression, of BDV was drastically inhibited by depletion of cellular cholesterol levels. BDV G-mediated attachment to BDV-susceptible cells was cholesterol independent, but G localized to lipid rafts (LR) at the plasma membrane. LR structure and function critically depend on cholesterol, and hence, compromised structural integrity and function of LR caused by cholesterol depletion likely inhibited the initial stages of BDV cell internalization. Furthermore, we also show that viral-envelope cholesterol is required for BDV infectivity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.