ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
State-, timing-, and pattern-dependent neuromodulation of synaptic strength by a serotonergic interneuron.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Biological detail and graph structure in network neuroscience.Frontiers in network physiology · 2025Review
- The Consistency of Gastropod Identified Neurons Distinguishes Intra-Individual Plasticity From Inter-Individual Variability in Neural Circuits.Frontiers in behavioral neuroscience · 2022Review
- Recognition of letters displayed as successive contour fragments.AIMS neuroscience · 2022Article
- Neurochemistry of Visual Attention.Frontiers in neuroscience · 2021Review
- Stability of working memory in continuous attractor networks under the control of short-term plasticity.PLoS computational biology · 2019Article
- Use of theJournal of neurophysiology · 2017Review
- Watching a memory form-VSD imaging reveals a novel memory mechanism.Communicative & integrative biology · 2016Article
- Neuromodulation as a mechanism for the induction of repetition priming.Current opinion in neurobiology · 2014Review
- Neuromodulation of neurons and synapses.Current opinion in neurobiology · 2014Review
- Article
- Parallel evolution of serotonergic neuromodulation underlies independent evolution of rhythmic motor behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Removal of default state-associated inhibition during repetition priming improves response articulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Neuromodulator-evoked synaptic metaplasticity within a central pattern generator network.Journal of neurophysiology · 2012Article
- Modulation of circuit feedback specifies motor circuit output.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Peptide neuromodulation of synaptic dynamics in an oscillatory network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Gastric and pyloric motor pattern control by a modulatory projection neuron in the intact crab Cancer pagurus.Journal of neurophysiology · 2011Article
- Beyond the wiring diagram: signalling through complex neuromodulator networks.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Composite modulatory feedforward loop contributes to the establishment of a network state.Journal of neurophysiology · 2010Article
- NeuronBank: A Tool for Cataloging Neuronal Circuitry.Frontiers in systems neuroscience · 2010Article
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Authors and funding
2 authors.
Funding
Abstract
Here we report that a serotonergic neuron evokes two distinct neuromodulatory actions with different state, timing, and firing pattern dependencies. These neuromodulatory actions may have important behavioral functions. In the mollusc, Tritonia diomedea, EPSCs evoked by ventral swim interneuron B (VSI) exhibited intrinsic plasticity; after a spike train, EPSC amplitude increased from a basal state to a potentiated state, which usually lasted >10 min. While the synapse was in a potentiated state, stimulation of a serotonergic dorsal swim interneuron (DSI) decreased VSI synaptic strength, returning it to a basal state. The extent of the DSI-evoked decrement was strongly correlated with the magnitude of the homosynaptic potentiation. This synaptic reset, or depotentiation, by DSI was blocked by the serotonin receptor antagonist methysergide and mimicked by a serotonin puff. In contrast to this state-dependent neuromodulatory action, we found that a previously described DSI-evoked transient enhancement of VSI synaptic strength was state-independent, producing the same multiplicative increase in EPSC amplitude regardless of whether the synapse was in a potentiated or basal state. These two actions also differed in their dependencies on the firing pattern of DSI and VSI action potentials. Results suggest that state-independent synaptic enhancement by DSI may play a short-term role during a swim motor pattern, whereas state-dependent actions may have longer-lasting consequences, resetting VSI synaptic strength after a swim bout. Thus, differences in two neuromodulatory actions at one synapse may allow a serotonergic neuron to play distinct roles at different stages of a motor pattern.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.