ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Homeostatic control of sensory output in basal vomeronasal neurons: activity-dependent expression of ether-à-go-go-related gene potassium channels.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Purkinje cell hyperexcitability and depressive-like behavior in mice lacking erg3 (ether-à-go-go-related gene) KScience advances · 2024Article
- Article
- A revised conceptual framework for mouse vomeronasal pumping and stimulus sampling.Current biology : CB · 2024Article
- Locus Coeruleus Neurons' Firing Pattern Is Regulated by ERG Voltage-Gated KInternational journal of molecular sciences · 2022Article
- The ERG1 KFrontiers in molecular neuroscience · 2022Review
- Article
- Signal Detection and Coding in the Accessory Olfactory System.Chemical senses · 2018Review
- Ether-à-go-go KThe Journal of physiology · 2018Review
- Antiarrhythmics cure brain arrhythmia: The imperativeness of subthalamic ERG KScience advances · 2017Article
- In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ.Journal of visualized experiments : JoVE · 2016Article
- Extracellular pH regulates excitability of vomeronasal sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Article
- Article
- Physiological characterization of formyl peptide receptor expressing cells in the mouse vomeronasal organ.Frontiers in neuroanatomy · 2014Article
- Article
- Erg potassium currents of neonatal mouse Purkinje cells exhibit fast gating kinetics and are inhibited by mGluR1 activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Paradoxical contribution of SK3 and GIRK channels to the activation of mouse vomeronasal organ.Nature neuroscience · 2012Article
- Contribution of EAG to excitability and potassium currents in Drosophila larval motoneurons.Journal of neurophysiology · 2012Article
- Mitochondrial Ca(2+) mobilization is a key element in olfactory signaling.Nature neuroscience · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conspecific chemosensory communication controls a broad range of social and sexual behaviors. In most mammals, social chemosignals are predominantly detected by sensory neurons of a specialized olfactory subsystem, the vomeronasal organ (VNO). The behavioral relevance of social chemosignaling puts high demands on the accuracy and dynamic range of the underlying transduction mechanisms. However, the physiological concepts implemented to ensure faithful transmission of social information remain widely unknown. Here, we show that sensory neurons in the basal layer of the mouse VNO dynamically control their input-output relationship by activity-dependent regulation of K(+) channel gene expression. Using large-scale expression profiling, immunochemistry, and electrophysiology, we provide molecular and functional evidence for a role of ether-à-go-go-related gene (ERG) K(+) channels as key determinants of cellular excitability. Our findings indicate that an increase in ERG channel expression extends the dynamic range of the stimulus-response function in basal vomeronasal sensory neurons. This novel mechanism of homeostatic plasticity in the periphery of the accessory olfactory system is ideally suited to adjust VNO neurons to a target output range in a layer-specific and use-dependent manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.