ArticleJournal of neurophysiology2009
Bitter-responsive gustatory neurons in the rat parabrachial nucleus.
Article in Journal of neurophysiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 55 citations in OpenAlex.
- ParabrachialeNeuro · 2025Article
- A Novel Mechanism for T1R-Independent Taste Responses to Concentrated Sugars.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- TRPV1-Lineage Somatosensory Fibers Communicate with Taste Neurons in the Mouse Parabrachial Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Encoding Taste: From Receptors to Perception.Handbook of experimental pharmacology · 2022Article
- Key Factors Affecting the Flesh Flavor Quality and the Nutritional Value of Grass Carp in Four Culture Modes.Foods (Basel, Switzerland) · 2021Article
- Functional and Neurochemical Identification of Ghrelin Receptor (GHSR)-Expressing Cells of the Lateral Parabrachial Nucleus in Mice.Frontiers in neuroscience · 2021Article
- Two neuronal groups for NaCl with differential taste response properties and topographical distributions in the rat parabrachial nucleus.Physiological reports · 2020Article
- Electrophysiological responses to sugars and amino acids in the nucleus of the solitary tract of type 1 taste receptor double-knockout mice.Journal of neurophysiology · 2020Article
- Rats are unable to discriminate quinine from diverse bitter stimuli.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Interaction of Taste and Place Coding in the Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Recognizing Taste: Coding Patterns Along the Neural Axis in Mammals.Chemical senses · 2019Review
- Mouse Parabrachial Neurons Signal a Relationship between Bitter Taste and Nociceptive Stimuli.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Central taste anatomy and physiology.Handbook of clinical neurology · 2019Review
- The Functional and Neurobiological Properties of Bad Taste.Physiological reviews · 2019Review
- The Parabrachial Nucleus: CGRP Neurons Function as a General Alarm.Trends in neurosciences · 2018Review
- Taste buds: cells, signals and synapses.Nature reviews. Neuroscience · 2017Review
- Taste coding of complex naturalistic taste stimuli and traditional taste stimuli in the parabrachial pons of the awake, freely licking rat.Journal of neurophysiology · 2016Article
- Dynamic taste responses of parabrachial pontine neurons in awake rats.Journal of neurophysiology · 2016Article
- Topographic organizations of taste-responsive neurons in the parabrachial nucleus of C57BL/6J mice: An electrophysiological mapping study.Neuroscience · 2016Article
- Taste coding in the parabrachial nucleus of the pons in awake, freely licking rats and comparison with the nucleus of the solitary tract.Journal of neurophysiology · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Bitterness is a distinctive taste sensation, but central coding for this quality remains enigmatic. Although some receptor cells and peripheral fibers are selectively responsive to bitter ligands, central bitter responses are most typical in broadly tuned neurons. Recently we reported more specifically tuned bitter-best cells (B-best) in the nucleus of the solitary tract (NST). Most had glossopharyngeal receptive fields and few projected to the parabrachial nucleus (PBN), suggesting a role in reflexes. To determine their potential contribution to other functions, the present study investigated whether B-best neurons occur further centrally. Responses from 90 PBN neurons were recorded from anesthetized rats. Stimulation with four bitter tastants (quinine, denatonium, propylthiouracil, cycloheximide) and sweet, umami, salty, and sour ligands revealed a substantial proportion of B-best cells (22%). Receptive fields for B-best NST neurons were overwhelmingly foliate in origin, but in PBN, about half received foliate and nasoincisor duct input. Despite convergence, most B-best PBN neurons were as selectively tuned as their medullary counterparts and response profiles were reliable. Regardless of intensity, cycloheximide did not activate broadly tuned acid/sodium (AN) neurons but did elicit robust responses in B-best cells. However, stronger quinine activated AN neurons and concentrated electrolytes stimulated B-best cells, suggesting that B-best neurons might contribute to higher-order functions such as taste quality coding but work in conjunction with other cell types to unambiguously signal bitter-tasting ligands. In this ensemble, B-best neurons would help discriminate sour from bitter stimuli, whereas AN neurons might be more important in differentiating ionic from nonionic bitter stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.