ArticleNucleic acids research2009
Cisplatin induces loop structures and condensation of single DNA molecules.
Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 115 citations in OpenAlex.
- Facile synthesis of platinated DNA nanoparticles with radiosensitizing potential.Beilstein journal of nanotechnology · 2026Article
- A trackable trinuclear platinum complex for breast cancer treatment.Nucleic acids research · 2025Article
- DNA binding to small anionic ligands: the case of Orange G dye.European biophysics journal : EBJ · 2025Article
- Probing the potential of rare earth elements in the development of new anticancer drugs: single molecule studies.Beilstein journal of nanotechnology · 2025Article
- Characteristic effect of hydroxyurea on the higher-order structure of DNA and gene expression.Scientific reports · 2024Article
- Article
- Cisplatin fastens chromatin irreversibly even at a high chloride concentration.Nucleic acids research · 2021Article
- Atomic force microscopy-A tool for structural and translational DNA research.APL bioengineering · 2021Review
- Heat treatment and protective potentials of luteolin-7-O-glucoside against cisplatin genotoxic and cytotoxic effects.Environmental science and pollution research international · 2020Article
- Different Effects of Cisplatin and Transplatin on the Higher-Order Structure of DNA and Gene Expression.International journal of molecular sciences · 2019Article
- Infrared nanospectroscopic mapping of a single metaphase chromosome.Nucleic acids research · 2019Article
- Article
- Article
- Analysis of single, cisplatin-induced DNA bends by atomic force microscopy and simulations.Journal of molecular recognition : JMR · 2018Article
- Catalysis of a 1,3-dipolar reaction by distorted DNA incorporating a heterobimetallic platinum(ii) and copper(ii) complex.Chemical science · 2017Article
- Interaction of Newly Platinum(II) with Tris(2-carboxyethyl)phosphine Complex with DNA and Model Lipid Membrane.The Journal of membrane biology · 2017Article
- Direct measurement of interaction forces between a platinum dichloride complex and DNA molecules.Journal of biological physics · 2017Article
- Article
- Platinum-Based Drugs and DNA Interactions Studied by Single-Molecule and Bulk Measurements.Biophysical journal · 2016Article
- AFM of self-assembled lambda DNA-histone networks.Colloids and surfaces. B, Biointerfaces · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Structural properties of single lambda DNA treated with anti-cancer drug cisplatin were studied with magnetic tweezers and AFM. Under the effect of low-concentration cisplatin, the DNA became more flexible, with the persistence length decreased significantly from approximately 52 to 15 nm. At a high drug concentration, a DNA condensation phenomenon was observed. Based on experimental results from both single-molecule and AFM studies, we propose a model to explain this kind of DNA condensation by cisplatin: first, di-adducts induce local distortions of DNA. Next, micro-loops of approximately 20 nm appear through distant crosslinks. Then, large aggregates are formed through further crosslinks. Finally, DNA is condensed into a compact globule. Experiments with Pt(dach)Cl(2) indicate that oxaliplatin may modify the DNA structures in the same way as cisplatin. The observed loop structure formation of DNA may be an important feature of the effect of platinum anti-cancer drugs that are analogous to cisplatin in structure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.