ArticleNucleic acids research2009
Molecular characterization of Mybbp1a as a co-repressor on the Period2 promoter.
Article in Nucleic acids research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Parallel and convergent evolution in genes underlying seasonal migration.Evolution letters · 2025Article
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- The lupus autoantigen La/Ssb is an Xist-binding protein involved in Xist folding and cloud formation.Nucleic acids research · 2021Article
- Growth of pancreatic cancers with hemizygous chromosomal 17p loss ofScience advances · 2020Article
- The pVHL neglected functions, a tale of hypoxia-dependent and -independent regulations in cancer.Open biology · 2020Review
- The Tumor Suppressor Roles of MYBBP1A, a Major Contributor to Metabolism Plasticity and Stemness.Cancers · 2020Review
- The Super-Enhancer-Derived alncRNA-EC7/Bloodlinc Potentiates Red Blood Cell Development in trans.Cell reports · 2017Article
- Prognostic relevance of Period1 (Per1) and Period2 (Per2) expression in human gastric cancer.International journal of clinical and experimental pathology · 2014Article
- Aberrant expression of Per1, Per2 and Per3 and their prognostic relevance in non-small cell lung cancer.International journal of clinical and experimental pathology · 2014Article
- Dissecting the roles of tyrosines 490 and 785 of TrkA protein in the induction of downstream protein phosphorylation using chimeric receptors.The Journal of biological chemistry · 2013Article
- MYBBP1A suppresses breast cancer tumorigenesis by enhancing the p53 dependent anoikis.BMC cancer · 2013Article
- Article
- Genetic insights on sleep schedules: this time, it's PERsonal.Trends in genetics : TIG · 2012Review
- Rhythmic binding of Topoisomerase I impacts on the transcription of Bmal1 and circadian period.Nucleic acids research · 2012Article
- Myb-binding protein 1a (Mybbp1a) regulates levels and processing of pre-ribosomal RNA.The Journal of biological chemistry · 2012Article
- Epigeneitc silencing of ribosomal RNA genes by Mybbp1a.Journal of biomedical science · 2012Article
- Proteomic analysis of mitotic RNA polymerase II reveals novel interactors and association with proteins dysfunctional in disease.Molecular & cellular proteomics : MCP · 2012Article
- Epigenetic silencing of myogenic gene program by Myb-binding protein 1a suppresses myogenesis.The EMBO journal · 2012Article
- Abnormal expression of PER1 circadian-clock gene in oral squamous cell carcinoma.OncoTargets and therapy · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The circadian clock comprises transcriptional feedback loops of clock genes. Cryptochromes are essential components of the negative feedback loop in mammals as they inhibit CLOCK-BMAL1-mediated transcription. We purified mouse CRY1 (mCRY1) protein complexes from Sarcoma 180 cells to determine their roles in circadian gene expression and discovered that Myb-binding protein 1a (Mybbp1a) interacts with mCRY1. Mybbp1a regulates various transcription factors, but its role in circadian gene expression is unknown. We found that Mybbp1a functions as a co-repressor of Per2 expression and repressed Per2 promoter activity in reporter assays. Chromatin immunoprecipitation (ChIP) assays revealed endogenous Mybbp1a binding to the Per2 promoter that temporally matched that of mCRY1. Furthermore, Mybbp1a binding to the Per2 promoter correlated with the start of the down-regulation of Per2 expression and with the dimethylation of histone H3 Lys9, to which it could also bind. These findings suggest that Mybbp1a and mCRY1 can form complexes on the Per2 promoter that function as negative regulators of Per2 expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.