ArticleThe Journal of biological chemistry2009
The Drosophila melanogaster Gene cg4930 Encodes a High Affinity Inhibitor for Endonuclease G.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- KU80 suppresses endonuclease G activity to preserve genomic integrity.The FEBS journal · 2026Article
- Discovery of an Endonuclease G-inhibitory Ku80-peptide protecting against leukemogenic rearrangements at the MLL breakpoint cluster.Nature communications · 2026Article
- Time-Course Transcriptomic Analysis of Early Host Responses to Oral SfMNPV Challenge inInsects · 2026Article
- Structural adaptation of vertebrate endonuclease G for 5-hydroxymethylcytosine recognition and function.Nucleic acids research · 2020Article
- Oligoadenylation of 3' decay intermediates promotes cytoplasmic mRNA degradation in Drosophila cells.RNA (New York, N.Y.) · 2016Article
- Novel cytoprotective inhibitors for apoptotic endonuclease G.DNA and cell biology · 2015Article
- Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination.Nucleic acids research · 2014Article
- Mutations in PRKN and SNCA Genes Important for the Progress of Parkinson's Disease.Current genomics · 2013Article
- Uropathogenic specific protein gene, highly distributed in extraintestinal uropathogenic Escherichia coli, encodes a new member of H-N-H nuclease superfamily.Gut pathogens · 2013Article
- Identification of Drosophila and human 7-methyl GMP-specific nucleotidases.The Journal of biological chemistry · 2013Article
- Barriers to male transmission of mitochondrial DNA in sperm development.Developmental cell · 2012Article
- Structural insights into apoptotic DNA degradation by CED-3 protease suppressor-6 (CPS-6) from Caenorhabditis elegans.The Journal of biological chemistry · 2012Article
- Structural insights into the effector-immunity system Tse1/Tsi1 from Pseudomonas aeruginosa.PloS one · 2012Article
- Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function.Nature · 2011Article
- Arginine methylation of the nuclear poly(a) binding protein weakens the interaction with its nuclear import receptor, transportin.The Journal of biological chemistry · 2011Article
- Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation.RNA (New York, N.Y.) · 2010Article
- Mechanisms of apoptosis in Crustacea: What conditions induce versus suppress cell death?Apoptosis : an international journal on programmed cell death · 2010Review
- Cellular and nuclear degradation during apoptosis.Current opinion in cell biology · 2009Review
- Crystal structure of the EndoG/EndoGI complex: mechanism of EndoG inhibition.Nucleic acids research · 2009Article
- Purification, crystallization and data collection of the apoptotic nuclease endonuclease G.Acta crystallographica. Section F, Structural biology and crystallization communications · 2009Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endonuclease G (EndoG) is a mitochondrial enzyme believed to be released during apoptosis to participate in the degradation of nuclear DNA. This paper describes a Drosophila protein, EndoGI, which inhibits EndoG specifically. EndoG and EndoGI associate with subpicomolar affinity, forming a 2:1 complex in which dimeric EndoG is bound by two tandemly repeated homologous domains of monomeric EndoGI. Binding appears to involve the active site of EndoG. EndoGI is present in the cell nucleus at micromolar concentrations. Upon induction of apoptosis, levels of the inhibitor appear to be reduced, and it is relocalized to the cytoplasm. EndoGI, encoded by the predicted open reading frame cg4930, is expressed throughout Drosophila development. Flies homozygous for a hypomorphic EndoGI mutation have a strongly reduced viability, which is modulated by genetic background and diet. We propose that EndoGI protects the cell against low levels of EndoG outside mitochondria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.