ArticleProceedings. Biological sciences2009
Sex-specific variation in the emphasis, inducibility and timing of the post-mating immune response in Drosophila melanogaster.
Article in Proceedings. Biological sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
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- Ovariole number does not predict reproductive output or trade-off with immunity in Drosophila melanogaster.PloS one · 2025Article
- Is there a sicker sex? Dose relationships modify male-female differences in infection prevalence.Proceedings. Biological sciences · 2024Article
- Maize adaptation across temperate climates was obtained via expression of two florigen genes.PLoS genetics · 2020Article
- Origin of tuberculosis in the Paleolithic predicts unprecedented population growth and female resistance.Scientific reports · 2020Article
- Divergence in Transcriptional and Regulatory Responses to Mating in Male and Female Fruitflies.Scientific reports · 2019Article
- Sexual Dimorphisms in Innate Immunity and Responses to Infection inFrontiers in immunology · 2019Review
- The effects of a bacterial challenge on reproductive success of fruit flies evolved under low or high sexual selection.Ecology and evolution · 2018Article
- The Toll pathway underlies host sexual dimorphism in resistance to both Gram-negative and Gram-positive bacteria in mated Drosophila.BMC biology · 2017Article
- Y-linked variation for autosomal immune gene regulation has the potential to shape sexually dimorphic immunity.Proceedings. Biological sciences · 2015Article
- The effect of parasites on sex differences in selection.Heredity · 2015Article
- Immune activation decreases sperm viability in both sexes and influences female sperm storage.Proceedings. Biological sciences · 2012Article
- Temporally variable selection on proteolysis-related reproductive tract proteins in Drosophila.Molecular biology and evolution · 2012Article
- Functional correlates of positional and gender-specific renal asymmetry in Drosophila.PloS one · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ecological immunology attempts to explain variation in immune function. Much of this work makes predictions about how potential hosts should invest in overall immunity. However, this 'overall' perspective under-emphasizes other critical aspects, such as the specificity, inducibility and timing of an immune response. Here, we investigate these aspects by examining gene regulation across several immune system components in both male and female Drosophila melanogaster prior to and after mating. To elucidate potentially important temporal dynamics, we also assayed several genes over time. We found that males and females emphasized different components of their immune system, however overall investment was similar. Specifically, the sexes emphasized different gene paralogues within major gene families, and males tended to invest more in gram-negative defence. By contrast, the inducibility of the immune response was both transient (lasting approx. 24 hours) and equal between the sexes. Furthermore, mating tended to induce humoral gene upregulation, while cell-mediated genes were unaffected. Within the humoral system, gram-negative bacterial defence genes exhibited a greater inducibility than those associated with fungal or gram-positive bacterial defence. Our results suggest that variation in the effectiveness of the immune response between the sexes may be driven by differences in emphasis rather than overall investment.
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