ArticleBMC evolutionary biology2009
Molecular evolution of UCP1 and the evolutionary history of mammalian non-shivering thermogenesis.
Article in BMC evolutionary biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Regulatory modules of human thermogenic adipocytes: functional genomics of large cohort and Meta-analysis derived marker-genes.BMC genomics · 2021Pooled it
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- Evidence of selection in the uncoupling protein 1 gene region suggests local adaptation to solar irradiance in savannah monkeys (Proceedings. Biological sciences · 2022Article
- Population genomics reveals that natural variation inZoological research · 2022Article
- Recurrent erosion of COA1/MITRAC15 exemplifies conditional gene dispensability in oxidative phosphorylation.Scientific reports · 2021Article
- Pros and cons for the evidence of adaptive non-shivering thermogenesis in marsupials.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Review
- Another Weapon against Cancer and Metastasis: Physical-Activity-Dependent Effects on Adiposity and Adipokines.International journal of molecular sciences · 2021Review
- Journey to a Receptor for Advanced Glycation End Products Connection in Severe Acute Respiratory Syndrome Coronavirus 2 Infection: With Stops Along the Way in the Lung, Heart, Blood Vessels, and Adipose Tissue.Arteriosclerosis, thrombosis, and vascular biology · 2021Review
- What Animal Cancers teach us about Human Biology.Theranostics · 2021Review
- Emergent Coordination of the CHKB and CPT1B Genes in Eutherian Mammals: Implications for the Origin of Brown Adipose Tissue.Journal of molecular biology · 2020Article
- Coevolution of body size and metabolic rate in vertebrates: a life-history perspective.Biological reviews of the Cambridge Philosophical Society · 2020Article
- Thermogenic adipocytes: lineage, function and therapeutic potential.The Biochemical journal · 2020Review
- The evolution of mechanisms involved in vertebrate endothermy.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Association of leukemia and mitochondrial diseases-A review.Journal of family medicine and primary care · 2019Review
- Targeting White Adipose Tissue with Exercise or Bariatric Surgery as Therapeutic Strategies in Obesity.Biology · 2019Review
- The Impact of Early Human Migration on Brown Adipose Tissue Evolution and Its Relevance to the Modern Obesity Pandemic.Journal of the Endocrine Society · 2019Review
- Evolutionary Genetics of Hypoxia and Cold Tolerance in Mammals.Journal of molecular evolution · 2018Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUncoupling protein 1 (UCP1) is a mitochondrial anion carrier, expressed in brown adipose tissue (BAT) of Eutherians. UCP1 is responsible for uncoupling mitochondrial proton transport from the production of ATP, thereby dissipating heat; it is essential for non-shivering thermogenesis (NST) in mammalian BAT. UCP1 orthologs have been identified in non-Eutherian mammals, fish and amphibians. Yet, UCP1 has a unique function in Eutherians in that it is necessary in the production of heat (NST). As such, this study aims to determine the evolutionary mode of UCP1 in Eutherians, where there is clear evidence of UCP1-dependent NST in BAT.
resultsModels of adaptive evolution through phylogenetic analysis of amino acid sequences by maximum likelihood were implemented to determine the mode of UCP1 protein evolution in Eutherians. An increase in the rate of amino acid substitutions on the branch leading to Eutherians is observed, but is best explained by relaxed constraints, not positive selection. Further, evidence for branch and site heterogeneity in selection pressures, as well as divergent selection pressures between UCP1 and its paralogs (UCP2-3) is observed.
conclusionWe propose that the unique thermogenic function of UCP1 in Eutherians may be best explained by neutral processes. Along with other evidence, this suggests that the primary biochemical properties of UCP1 may not differ between Eutherians and non-Eutherians.
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