ArticlePaediatric drugs2009
Potential role of the placenta in fetal alcohol spectrum disorder.
Article in Paediatric drugs, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Maternal Chronic Ethanol Exposure Decreases Stress Responses in Zebrafish Offspring.Biomolecules · 2022Article
- Maternal exposure to prostaglandin EBiochemistry and biophysics reports · 2018Article
- Placental Proteomics Reveal Insights into Fetal Alcohol Spectrum Disorders.Alcoholism, clinical and experimental research · 2017Article
- Ethyl linolenate is elevated in meconium of very-low-birth-weight neonates exposed to alcohol in utero.Pediatric research · 2017Article
- Alcohol-Induced Developmental Origins of Adult-Onset Diseases.Alcoholism, clinical and experimental research · 2016Review
- Fetal alcohol-spectrum disorders: identifying at-risk mothers.International journal of women's health · 2016Review
- Fatty acid ethyl esters disrupt neonatal alveolar macrophage mitochondria and derange cellular functioning.Alcoholism, clinical and experimental research · 2015Article
- Placental Fatty Acid ethyl esters are elevated with maternal alcohol use in pregnancies complicated by prematurity.PloS one · 2015Article
- Fetal alcohol spectrum disorders.European child & adolescent psychiatry · 2014Review
- Perinatal exposure to alcohol: implications for lung development and disease.Paediatric respiratory reviews · 2013Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMediators of susceptibility to alcohol-related toxicity in the prenatal environment are relatively unknown. The placenta has been proposed as a potential source of variability in the fetal environment, primarily through its significant metabolic capabilities. Meconium is a toxicological matrix unique to the developing fetus that offers an opportunity to quantify fetal exposure to alcohol through the analysis of fatty acid ethyl esters (FAEE) [nonoxidative ethanol metabolites].
objectiveTo explore the role of the placenta as a potential source of variability in mediating fetal alcohol exposure via meconium analysis of FAEE, by combining a clinical case report involving human dizygotic twins and a series of guinea pig littermates.
methodsMeconium was collected from a pair of dizygotic twins with clinical suspicion of prenatal alcohol exposure and analyzed for FAEE to confirm prenatal alcohol exposure. Meconium was also collected from a series of guinea pig pups prenatally exposed to alcohol at a daily dose of 4 g/kg/day administered to the pregnant dam. FAEE levels were analyzed by gas chromatography with flame ionization detection following liquid-liquid extraction from meconium.
resultsThe dizygotic twin pair yielded positive meconium FAEE results (>2.00 nmoL/g) in the female twin (2.21 nmoL/g) and no detectable FAEE in the male twin. A total of 15 meconium samples were collected from 15 pups of five pregnant guinea pig litters. With the exception of one pair of littermates, meconium FAEE concentrations differed substantially within each litter (FAEE expressed in units of nmoL/g): litter 1 (0.996, 4.43, 1.36); litter 2 (5.17, 4.15, 0.00); litter 3 (5.16, 5.27); litter 4 (18.57, 8.26, 7.46); litter 5 (0.00, 4.32, 0.00, 1.27).
conclusionsIdentical maternal ethanol exposure levels produced differing levels of fetal exposure in a dizygotic human twin pair and a series of guinea pig littermates as evidenced through FAEE meconium analysis. These data indicate that the placenta may have a previously unappreciated role in mediating ethanol-induced fetal injury.
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