ArticleCurrent microbiology2009
HU participates in expression of a specific set of genes required for growth and survival at acidic pH in Escherichia coli.
Article in Current microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Identification and functional analysis of novel protein-encoding sequences related to stress-resistance.Frontiers in microbiology · 2023Article
- The soluble transhydrogenase UdhA affecting the glutamate-dependent acid resistance system ofBiology open · 2018Article
- Survival of Helicobacter pylori in gastric acidic territory.Helicobacter · 2017Review
- Bacterial histone-like proteins: roles in stress resistance.Current genetics · 2015Review
- DNA-Binding Protein HU Coordinates Pathogenicity in Vibrio parahaemolyticus.Journal of bacteriology · 2015Article
- A novel DNA-binding protein plays an important role in Helicobacter pylori stress tolerance and survival in the host.Journal of bacteriology · 2015Article
- Identification and characterization of outer membrane vesicle-associated proteins in Salmonella enterica serovar Typhimurium.Infection and immunity · 2014Article
- Integration host factor is required for the induction of acid resistance in Escherichia coli.Current microbiology · 2014Article
- The nucleoid-associated protein HUβ affects global gene expression in Porphyromonas gingivalis.Microbiology (Reading, England) · 2013Article
- A histone-like protein of Helicobacter pylori protects DNA from stress damage and aids host colonization.DNA repair · 2012Article
- ATP requirement for acidic resistance in Escherichia coli.Journal of bacteriology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The major histone-like Escherichia coli protein, HU, is composed of alpha and beta subunits respectively encoded by hupA and hupB in Escherichia coli. A mutant deficient in both hupA and hupB grew at a slightly slower rate than the wild type at pH 7.5. Growth of the mutant diminished with a decrease in pH, and no growth was observed at pH 4.6. Mutants of either hupA or hupB grew at all pH levels tested. The arginine-dependent survival at pH 2.5 was diminished approximately 60-fold by the deletion of both hupA and hupB, whereas the survival was slightly affected by the deletion of either hupA or hupB. The mRNA levels of adiA and adiC, which respectively encode arginine decarboxylase and arginine/agmatine antiporter, were low in the mutant deficient in both hupA and hupB. The deletion of both hupA and hupB had little effect on survival at pH 2.5 in the presence of glutamate or lysine, and expression of the genes for glutamate and lysine decarboxylases was not impaired by the deletion of the HU genes. These results suggest that HU regulates expression of the specific set of genes required for growth and survival in acidic environments.
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