ArticleMolecules (Basel, Switzerland)2008
Differential cytotoxicity of MEX: a component of Neem oil whose action is exerted at the cell membrane level.
Article in Molecules (Basel, Switzerland), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 37 citations in OpenAlex.
- Pioneering study of Egyptian Neem and Jojoba extracts with molecular docking combat hospital multidrug resistant bacteria.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Functional genomics screen with pooled shRNA library and gene expression profiling with extracts ofPeerJ · 2019Article
- An Overview on the Anticancer Activity ofInternational journal of molecular sciences · 2018Review
- Neem Seed Oil Induces Apoptosis in MCF-7 and MDA MB-231 Human Breast Cancer CellsAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Nanocapsules Containing Neem (Azadirachta Indica) Oil: Development, Characterization, And Toxicity Evaluation.Scientific reports · 2017Article
- Antibacterial activity of neem nanoemulsion and its toxicity assessment on human lymphocytes in vitro.International journal of nanomedicine · 2015Article
- Neem components as potential agents for cancer prevention and treatment.Biochimica et biophysica acta · 2014Review
- Structure and electronic properties of azadirachtin.Journal of molecular modeling · 2014Article
- Resveratrol exhibits a strong cytotoxic activity in cultured cells and has an antiviral action against polyomavirus: potential clinical use.Journal of experimental & clinical cancer research : CR · 2009Article
- Alterations of the plasma membrane caused by murine polyomavirus proliferation: an electrorotation study.The Journal of membrane biology · 2009Article
- A review of the anticancer activity of Azadirachta indica (Neem) in oral cancer.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neem oil is obtained from the seeds of the tree Azadirachta indica. Its chemical composition is very complex, being rich in terpenoids and limonoids, as well as volatile sulphur modified compounds. This work focused on the evaluation of a component of the whole Neem oil obtained by methanolic extraction and defined as MEX. Cytotoxicity was assessed on two different cell populations: a stabilized murine fibroblast line (3T6) and a tumor cell line (HeLa). The data presented here suggest a differential sensitivity of these two populations, the tumor line exhibiting a significantly higher sensitivity to MEX. The data strongly suggest that its toxic target is the cell membrane. In addition the results presented here imply that MEX may contain one or more agents that could find a potential use in anti-proliferative therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.