Evidence map›Paper›PMID 19126961›Full record

ReviewCancer biomarkers : section A of Disease markers2008

In vivo biomarkers for targeting colorectal neoplasms.

Pei-Lin Hsiung, Thomas Wang

Abstract readReview
In one paragraph

Review in Cancer biomarkers : section A of Disease markers, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Targeted imaging of flat and depressed colonic neoplasms.Gastrointestinal endoscopy clinics of North America · 2010
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Pei-Lin HsiungDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Thomas Wang

Funding

Task Specific Project 4U54CA136429 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI REHEMTULLA, ALNAWAZ · 2008 to 2012
$5.2M
Miniature Confocal Theta Flourescence MicroscopeR33CA109988 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WANG, THOMAS D · 2005 to 2007
$1.1M
Novel Confocal Microscope for Molecular/Cellular ImagingK08DK067618 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WANG, THOMAS D · 2003 to 2007
$607k
Peptide Reagents for Detection of Colonic DysplasiaR03DK075603 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WANG, THOMAS D · 2006 to 2007
$148k
NCI NIH HHS R33 CA109988NCI NIH HHS U54 CA136429NIDDK NIH HHS K08 DK067618NIDDK NIH HHS R03 DK075603
6 · The paper itself

Abstract

Colorectal carcinoma continues to be a leading cause of cancer morbidity and mortality despite widespread adoption of screening methods. Targeted detection and therapy using recent advances in our knowledge of in vivo cancer biomarkers promise to significantly improve methods for early detection, risk stratification, and therapeutic intervention. The behavior of molecular targets in transformed tissues is being comprehensively assessed using new techniques of gene expression profiling and high throughput analyses. The identification of promising targets is stimulating the development of novel molecular probes, including significant progress in the field of activatable and peptide probes. These probes are being evaluated in small animal models of colorectal neoplasia and recently in the clinic. Furthermore, innovations in optical imaging instrumentation are resulting in the scaling down of size for endoscope compatibility. Advances in target identification, probe development, and novel instruments are progressing rapidly, and the integration of these technologies has a promising future in molecular medicine.

Indexed as

Molecular Probe TechniquesAdenocarcinomaAnimalsBiomarkers, TumorColorectal NeoplasmsHumansBiomarkers, Tumor

Identifiers

PMID19126961
PMCPMC3232019

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.