ArticleJPEN. Journal of parenteral and enteral nutrition
Starvation-induced proximal gut mucosal atrophy diminished with aging.
Article in JPEN. Journal of parenteral and enteral nutrition. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Intestinal adaptations increase basolateral intestinal glucose uptake and glycolysis in a mouse model of cystic fibrosis.American journal of physiology. Gastrointestinal and liver physiology · 2026Article
- Microbes and diet reshape the intestine via distinct cellular dynamics.bioRxiv : the preprint server for biology · 2025Article
- Physiological and immunological aspects of feed restriction and its beneficial impacts in fattening rabbits' productivity-an updated review.Tropical animal health and production · 2024Review
- Age-dependent response to fasting during assessment of metabolizable energy and total tract digestibility in chicken.Poultry science · 2022Article
- METTL14 Regulates Intestine Cellular Senescence through mOxidative medicine and cellular longevity · 2022Article
- Heat Stress Directly Affects Intestinal Integrity in Broiler Chickens.The journal of poultry science · 2020Article
- Formula feeding and immature gut microcirculation promote intestinal hypoxia, leading to necrotizing enterocolitis.Disease models & mechanisms · 2019Article
- Schlafen 12 Interaction with SerpinB12 and Deubiquitylases Drives Human Enterocyte Differentiation.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2018Article
- Article
- A child with anorexia nervosa presenting with severe infection with cytopenia and hemophagocytosis: a case report.BioPsychoSocial medicine · 2017Article
- Histological aspects of the small intestine under variable feed restriction: The effects of short and intense restriction on a growing rabbit model.Experimental and therapeutic medicine · 2014Article
- Home enteral nutrition in children: a 14-year multicenter survey.European journal of clinical nutrition · 2013Article
- Intestinal mucosal atrophy and adaptation.World journal of gastroenterology · 2012Review
- Alanyl-glutamine promotes intestinal epithelial cell homeostasis in vitro and in a murine model of weanling undernutrition.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Proximal gut mucosal epithelial homeostasis in aged IL-1 type I receptor knockout mice after starvation.The Journal of surgical research · 2011Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundStarvation induces small bowel atrophy with increased intestinal epithelial apoptosis and decreased proliferation. The authors examined these parameters after starvation in aged animals.
methodsSixty-four 6-week-old and 26-month-old C57BL/6 mice were randomly assigned to either an ad libitum fed or fasted group. The small bowel was harvested at 12, 48, and 72 hours following starvation. Proximal gut mucosal height was measured and epithelial cells counted. Apoptosis was identified by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining. Proliferation was determined by immunohistochemical staining for proliferating cell nuclear antigen. Comparison of fed vs fasted and adult vs old groups was done by one-way ANOVA with Tukey's test and unpaired Student's t test. Significance was accepted at P < .05.
resultsAged mice had higher proximal gut weights, mucosal heights, and cell numbers at baseline compared with the adult group (P < .05). The rate of apoptosis was lower in the aged (P < .05), but proliferation was not different between groups before starvation. After starvation, proximal gut wet weight decreased only in adult mice (P < .05). Gut mucosal height and mucosal cell number decreased more in adult than in aged mice (P < .05). This was related to decreased proliferation only in the adult group (P < .05). The fold of epithelial apoptosis that increased was higher in the aged group than in the adult group after starvation (P < .05).
conclusionsGut mucosal kinetics change with age and have lower rates of apoptosis and greater mucosal mass; the character of starvation-induced atrophy is diminished with aging.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.