ArticlePloS one2009
IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D).
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 78 citations in OpenAlex.
- Case Report: IL2RA (CD25) deficiency: first reported cases in Morocco.Frontiers in immunology · 2026Article
- MSGD: a manually curated database of genomic, transcriptomic, proteomic and drug information for multiple sclerosis.Database : the journal of biological databases and curation · 2024Article
- A critical review on therapeutic approaches of CRISPR-Cas9 in diabetes mellitus.Naunyn-Schmiedeberg's archives of pharmacology · 2023Review
- Association ofReports of biochemistry & molecular biology · 2020Article
- Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated WithFrontiers in endocrinology · 2020Article
- RNASEH1 gene variants are associated with autoimmune type 1 diabetes in Colombia.Journal of endocrinological investigation · 2018Article
- The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part III: Polymorphisms of genes involved in Tregs' activation and function.Postepy dermatologii i alergologii · 2017Review
- Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells.Frontiers in immunology · 2017Review
- A 33D1+ Dendritic Cell/Autoreactive CD4+ T Cell Circuit Maintains IL-2-Dependent Regulatory T Cells in the Spleen.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Plasma Levels of Soluble Interleukin-2 Receptor α: Associations With Clinical Cardiovascular Events and Genome-Wide Association Scan.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Where is the causal variant? On the advantage of the family design over the case-control design in genetic association studies.European journal of human genetics : EJHG · 2015Article
- Tolerance of activated pathogenic CD4+ T cells by transcriptional targeting of dendritic cells.Gene therapy · 2015Article
- Comorbidities at multiple sclerosis diagnosis.Journal of neurology · 2013Article
- Evaluation of in vivo T cell kinetics: use of heavy isotope labelling in type 1 diabetes.Clinical and experimental immunology · 2013Article
- Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity.Clinical immunology (Orlando, Fla.) · 2013Article
- Genetic basis of alopecia areata: a roadmap for translational research.Dermatologic clinics · 2013Review
- In-vitro characterization of novel and functional regulatory SNPs in the promoter region of IL2 and IL2R alpha in a Gabonese population.BMC medical genetics · 2012Article
- Replication study of multiple sclerosis (MS) susceptibility alleles and correlation of DNA-variants with disease features in a cohort of Austrian MS patients.Neurogenetics · 2012Article
- Single nucleotide polymorphisms in multiple sclerosis: disease susceptibility and treatment response biomarkers.Immunologic research · 2012Review
- Determination of the real effect of genes identified in GWAS: the example of IL2RA in multiple sclerosis.European journal of human genetics : EJHG · 2012Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIL-2 receptor (IL2R) alpha is the specific component of the high affinity IL2R system involved in the immune response and in the control of autoimmunity. METHODS AND
resultsHere we perform a replication and fine mapping of the IL2RA gene region analyzing 3 SNPs previously associated with multiple sclerosis (MS) and 5 SNPs associated with type 1 diabetes (T1D) in a collection of 798 MS patients and 927 matched Caucasian controls from the south of Spain. We observed association with MS in 6 of 8 SNPs. The rs1570538, at the 3'- UTR extreme of the gene, previously reported to have a weak association with MS, is replicated here (P = 0.032). The most associated T1D SNP (rs41295061) was not associated with MS in the present study. However, the rs35285258, belonging to another independent group of SNPs associated with T1D, showed the maximal association in this study but different risk allele. We replicated the association of only one (rs2104286) of the two IL2RA SNPs identified in the recently performed genome-wide association study of MS.
conclusionsThese findings confirm and extend the association of this gene with MS and reveal a genetic heterogeneity of the associated polymorphisms and risk alleles between MS and T1D suggesting different immunopathological roles of IL2RA in these two diseases.
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