ArticleMediators of inflammation2008
Peripheral mononuclear cell resistin mRNA expression is increased in type 2 diabetic women.
Article in Mediators of inflammation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- High insulin and leptin increase resistin and inflammatory cytokine production from human mononuclear cells.BioMed research international · 2013Trial
- Obesity and Oral Health: The Link Between Adipokines and Periodontitis.TouchREVIEWS in endocrinology · 2024Review
- Characterization and Treatment of Inflammation and Insulin Resistance in Obese Adipose Tissue.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
- Association ofDiabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease.Frontiers in cardiovascular medicine · 2020Review
- Article
- IL-6 signalling pathways and the development of type 2 diabetes.Inflammopharmacology · 2018Review
- Sitagliptin decreases ventricular arrhythmias by attenuated glucose-dependent insulinotropic polypeptide (GIP)-dependent resistin signalling in infarcted rats.Bioscience reports · 2016Article
- Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease.Biochemia medica · 2015Article
- Resistin - 420 C/G polymorphism and serum resistin level in Iranian patients with gestational diabetes mellitus.Journal of diabetes and metabolic disorders · 2015Article
- MicroRNA-492 reverses high glucose-induced insulin resistance in HUVEC cells through targeting resistin.Molecular and cellular biochemistry · 2014Article
- Resistin in rodents and humans.Diabetes & metabolism journal · 2013Article
- Resistin: functional roles and therapeutic considerations for cardiovascular disease.British journal of pharmacology · 2012Review
- Article
- Downregulation of leptin and resistin expression in blood following bariatric surgery.Surgical endoscopy · 2011Article
- Serum CCL 18 Levels in Women with Polycystic Ovarian Syndrome.Indian journal of endocrinology and metabolismArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resistin has been shown to cause insulin resistance and to impair glucose tolerance in rodents, but in humans its physiological role still remains elusive. The aim of this study was to examine whether resistin mRNA expression in human peripheral mononuclear cells (PBMCs) and its corresponding plasma levels are altered in type 2 diabetes. Resistin mRNA levels were easily detectable in human PBMC, and found to be higher in DM2 compared to healthy women (P = .05). Similarly, mononuclear mRNA levels of the proinflammatory cytokines IL-1beta, TNF-alpha, and IL-6 were all significantly higher in DM2 compared to control women (P < .001). The corresponding plasma resistin levels were slightly, but not significantly, increased in DM2 women (P = .051), and overall, they correlated significantly with BMI (r = 0.406, P = .010) and waist circumference (r = 0.516, P = .003), but not with fasting insulin levels or HOMA-IR. Resistin mRNA expression is increased in PBMC from DM2 women, together with increased expression of the inflammatory cytokines IL-1beta, TNF-alpha, and IL-6, independent of obesity. These results suggest that resistin and cytokines might contribute to the low-grade inflammation and the increased atherogenic risk observed in these patients.
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