ArticleNature chemical biology2009
A natural ribozyme with 3',5' RNA ligase activity.
Article in Nature chemical biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Self-splicing and cyclization mechanisms of the full-length Anabaena pre-tRNA.Nature chemical biology · 2026Article
- Group I introns in tRNA genes of Patescibacteria.mSystems · 2026Article
- Self-splicing RNA circularization facilitated by intact group I and II introns.Nature communications · 2025Article
- Coevolution of reproducers and replicators at the origin of life and the conditions for the origin of genomes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Ribocentre: a database of ribozymes.Nucleic acids research · 2023Article
- Accumulation of Stable Full-Length Circular Group I Intron RNAs during Heat-Shock.Molecules (Basel, Switzerland) · 2016Article
- Crystal structure of a DNA catalyst.Nature · 2016Article
- The Biological Functions of Non-coding RNAs: From a Line to a Circle.Discoveries (Craiova, Romania) · 2015Review
- Evidence of liquid crystal-assisted abiotic ligation of nucleic acids.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2015Article
- RNA circularization strategies in vivo and in vitro.Nucleic acids research · 2015Review
- Circular RNAs: diversity of form and function.RNA (New York, N.Y.) · 2014Review
- Speciation of a group I intron into a lariat capping ribozyme.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Molecular characterization of a new member of the lariat capping twin-ribozyme introns.Mobile DNA · 2014Article
- There is no common ground between science and religion.Journal of biosciences · 2013Article
- The origin of life is a spatially localized stochastic transition.Biology direct · 2012Article
- Transcriptome-wide discovery of circular RNAs in Archaea.Nucleic acids research · 2012Article
- Self-circularizing 5'-ETS RNAs accumulate along with unprocessed pre ribosomal RNAs in growth-stressed Entamoeba histolytica.Scientific reports · 2012Article
- Origin of self-replicating biopolymers: autocatalytic feedback can jump-start the RNA world.Journal of molecular evolution · 2009Article
- Group I introns and inteins: disparate origins but convergent parasitic strategies.Journal of bacteriology · 2009Review
- A ghost in the RNA machine.Nature chemical biology · 2009Article
Corrections and comments
- Commented on by
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Using electrophoresis, sequencing and enzymatic digestion, we show that the group I intron from the cyanobacterium Anabaena sp. PCC 7120 catalyzes phosphodiester bond formation using a triphosphate on the 5'-terminal nucleotide, much like protein polymerases and engineered ribozymes. In the process, this ribozyme forms a unique circular RNA that incorporates the exogenous guanosine cofactor added during self-splicing. This finding may have relevance to a prebiotic RNA world and to modern biology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.