Evidence map›Paper›PMID 19125127›Full record

ReviewGenetics in medicine : official journal of the American College of Medical Genetics2009

EGAPP supplementary evidence review: DNA testing strategies aimed at reducing morbidity and mortality from Lynch syndrome.

Glenn E Palomaki, Monica R McClain, Stephanie Melillo, Heather L Hampel, Stephen N Thibodeau

Registry-linked trialAbstract readReview
In one paragraph

Review in Genetics in medicine : official journal of the American College of Medical Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01850654 (Ohio Colorectal Cancer Prevention Initiative), which is not on this map. Cited by 220 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
220citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01850654 nacompletednot on this mapstarted 2012, after this paper: background citation

Ohio Colorectal Cancer Prevention Initiative: Universal Screening for Lynch Syndrome

TypeinterventionalSponsorOhio State University Comprehensive Cancer CenterRan2012 to 2018Enrolled3,470ConditionsLynch Syndrome, Colorectal CancerArmsLS tumor screening, Genetic testing, Genetic Counseling, Biorepository, Questionnaire
3 · Its place in the literature

Who cites it

220 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Guideline
  2. Which Lynch syndrome screening programs could be implemented in the "real world"? A systematic review of economic evaluations.Genetics in medicine : official journal of the American College of Medical Genetics · 2018
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Guideline
  6. Guideline
  7. Uptake of genetic testing by relatives of lynch syndrome probands: a systematic review.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2013
    Pooled it
  8. Guideline
  9. Trial
  10. Trial
  11. Observational
  12. Review
  13. Article
  14. Cost-effectiveness of Lynch Syndrome Screening in Colorectal Cancer: Universal Germline vs Sequential Screening.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2025
    Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

160 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Glenn E PalomakiDepartment of Pathology and Laboratory Medicine, The Warren Alpert Medical School of Brown University, Women and Infants Hospital, Providence, Rhode Island, USA. gpalomaki@ipmms.org
Monica R McClain
Stephanie Melillo
Heather L Hampel
Stephen N Thibodeau

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

FamilyColorectal Neoplasms, Hereditary NonpolyposisCost-Benefit AnalysisGenetic CounselingGenetic TestingHumansMicrosatellite InstabilityMutationSensitivity and Specificity

Identifiers

PMID19125127
PMCPMC2743613

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.