ArticleProceedings of the National Academy of Sciences of the United States of America2009
Force amplification response of actin filaments under confined compression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- The impact of compression and confinement in tumor growth and progression: emerging concepts in cancer mechanobiology.Frontiers in materials · 2025Article
- Biomechanical, biophysical and biochemical modulators of cytoskeletal remodelling and emergent stem cell lineage commitment.Communications biology · 2023Review
- Molecular cancer cell responses to solid compressive stress and interstitial fluid pressure.Cytoskeleton (Hoboken, N.J.) · 2021Review
- Tissue engineered endometrial barrier exposed to peristaltic flow shear stresses.APL bioengineering · 2020Article
- An Integrated Cytoskeletal Model of Neurite Outgrowth.Frontiers in cellular neuroscience · 2018Review
- Myosin-Induced Gliding Patterns at Varied [MgATP] Unveil a Dynamic Actin Filament.Biophysical journal · 2016Article
- Near-atomic resolution for one state of F-actin.Structure (London, England : 1993) · 2015Article
- Power transduction of actin filaments ratcheting in vitro against a load.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- A mechanical-biochemical feedback loop regulates remodeling in the actin cytoskeleton.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Branching and capping determine the force-velocity relationships of branching actin networks.Physical biology · 2013Article
- Mathematical modeling of eukaryotic cell migration: insights beyond experiments.Annual review of cell and developmental biology · 2013Review
- Measuring forces at the leading edge: a force assay for cell motility.Integrative biology : quantitative biosciences from nano to macro · 2013Article
- A mechanochemical model of actin filaments.Biophysical journal · 2012Article
- Actin filaments as tension sensors.Current biology : CB · 2012Review
- Force-velocity measurements of a few growing actin filaments.PLoS biology · 2011Article
- Force-velocity relation for actin-polymerization-driven motility from Brownian dynamics simulations.Biophysical journal · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Actin protein is a major component of the cell cytoskeleton, and its ability to respond to external forces and generate propulsive forces through the polymerization of filaments is central to many cellular processes. The mechanisms governing actin's abilities are still not fully understood because of the difficulty in observing these processes at a molecular level. Here, we describe a technique for studying actin-surface interactions by using a surface forces apparatus that is able to directly visualize and quantify the collective forces generated when layers of noninterconnected, end-tethered actin filaments are confined between 2 (mica) surfaces. We also identify a force-response mechanism in which filaments not only stiffen under compression, which increases the bending modulus, but more importantly generates opposing forces that are larger than the compressive force. This elastic stiffening mechanism appears to require the presence of confining surfaces, enabling actin filaments to both sense and respond to compressive forces without additional mediating proteins, providing insight into the potential role compressive forces play in many actin and other motor protein-based phenomena.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.