Evidence map›Paper›PMID 19124763›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2009

Potent induction of IFN-alpha and chemokines by autoantibodies in the cerebrospinal fluid of patients with neuropsychiatric lupus.

Deanna M Santer, Taku Yoshio, Seiji Minota, Thomas Möller, Keith B Elkon

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 3 pooled it
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 3 syntheses or guidelines pooled it, 153 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Interferon Inhibition in SLE: From Bench to Bedside.Mediterranean journal of rheumatology · 2024
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Deanna M SanterDepartment of Immunology, University of Washington, Seattle, WA 98195, USA.
Taku Yoshio
Seiji Minota
Thomas Möller
Keith B Elkon
Jichi Medical University · JPUniversity of Washington · US

Funding

Apoptotic Cells As Immunogens In SLER01AR048796 · NIAMS · UNIVERSITY OF WASHINGTON · PI ELKON, KEITH B. · 2001 to 2010
$2.7M
Nucleoprotein Immune Complexes and Interferon in Diffuse Neuropsychiatric SLER21AR054980 · NIAMS · UNIVERSITY OF WASHINGTON · PI ELKON, KEITH B. · 2007 to 2008
$365k
NIAMS NIH HHS AR054980NIAMS NIH HHS AR48796NIAMS NIH HHS R01 AR048796NIAMS NIH HHS R21 AR054980
6 · The paper itself

Abstract

Neuropsychiatric disease in systemic lupus erythematosus (NPSLE) is a poorly understood, but potentially fatal, disease manifestation. A pathogenetic role for autoantibodies is suspected, but the mechanism is unclear. Since immune complexes in SLE can stimulate IFN-alpha and there is strong evidence in humans and in mice that IFN-alpha can cause neuropsychiatric manifestations, we asked whether NPSLE patient serum and/or cerebrospinal fluid (CSF) contain abnormally high IFN-alpha-inducing activity. In a bioassay containing plasmacytoid dendritic cells and a source of Ag, NPSLE CSF induced significantly higher IFN-alpha compared with CSF from patients with multiple sclerosis or other autoimmune disease controls. When normalized for IgG concentration, NPSLE CSF was 800-fold more potent at inducing IFN-alpha compared with paired serum due to inhibitors present in serum. Analysis of Ig-deficient patient serum, depletion of IgG from normal serum, as well as addition of purified IgG to NPSLE CSF and serum in the bioassays revealed that one inhibitor was contained within the IgG fraction itself. In addition to IFN-alpha, immune complexes formed by CSF autoantibodies produced significantly increased levels of IFN-gamma-inducible protein 10 (IP-10/CXCL), IL-8, and MCP-1, all of which have been reported to be elevated in CSF from NPSLE patients. Taken together, these findings are consistent with a two-step model of NPSLE whereby CSF autoantibodies bind to Ags released by neurocytotoxic Abs or other brain cell injury, and the resulting immune complexes stimulate IFN-alpha and proinflammatory cytokines and chemokines.

Indexed as

AdolescentAdultAgedAutoantibodiesCells, CulturedChemokine CCL2Chemokine CXCL10ChemokinesFemaleHeLa CellsHumansInterferon-alphaInterleukin-6Interleukin-8Lupus Vasculitis, Central Nervous SystemMaleAutoantibodiesCCL2 protein, humanChemokine CCL2Chemokine CXCL10ChemokinesCXCL10 protein, humanInterferon-alphaInterleukin-6Interleukin-8

Identifiers

PMID19124763
PMCPMC2745922
OpenAlexW2121592594

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.