ArticleJournal of immunology (Baltimore, Md. : 1950)2009
Sustained expression of pre-TCR induced beta-catenin in post-beta-selection thymocytes blocks T cell development.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Temporal regulation of Wnt/β-catenin signaling is important for invariant NKT cell development and terminal maturation.Molecular immunology · 2017Article
- WNT signaling suppression in the senescent human thymus.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- A critical role for the regulated wnt-myc pathway in naive T cell survival.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Article
- Developmental gene networks: a triathlon on the course to T cell identity.Nature reviews. Immunology · 2014Review
- Diacylglycerol metabolism attenuates T-cell receptor signaling and alters thymocyte differentiation.Cell death & disease · 2013Article
- Article
- β-catenin/TCF-1 pathway in T cell development and differentiation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Review
- T cell factor-1 and β-catenin control the development of memory-like CD8 thymocytes.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Multilayered specification of the T-cell lineage fate.Immunological reviews · 2010Review
- Article
- TCF1 and beta-catenin regulate T cell development and function.Immunologic research · 2010Review
- Bcl11b heterozygosity promotes clonal expansion and differentiation arrest of thymocytes in gamma-irradiated mice.Cancer science · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Pre-TCR and IL-7R signals regulate beta-selection of thymocytes and then must be down-regulated for further development. However, the molecular events that control down-regulation remain unknown. We and others have previously shown that beta-catenin in cooperation with TCF regulates beta-selection. In this paper, we demonstrate that beta-catenin expression is stringently regulated by intrathymic signals, it is expressed at the highest levels in the pre-TCR signaled thymocytes, and is down-regulated in post-beta-selection thymocytes. Pre-TCR-induced beta-catenin regulates initial stages of pre-TCR signaling including expression of early growth response (Egr) genes but must be down-regulated to express RORgammat, which is essential for maturation to the CD4+CD8+ double positive (DP) stage. Sustained expression of beta-catenin results in the generation of IL-7R-, Egr-, and TGFbeta-expressing pre-DP thymocytes that are blocked in development. These data are consistent with a model in which post-beta-selection, pre-TCR-induced beta-catenin expression must return to background levels for efficient transition to the DP stage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.