Evidence map›Paper›PMID 19124673›Full record

ReviewCirculation2009

Neurogenic orthostatic hypotension: a pathophysiological approach.

David S Goldstein, Yehonatan Sharabi

2 registry-linked trialsAbstract readReview
In one paragraph

Review in Circulation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 80 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02308124 phase4completednot on this mapstarted 2014, after this paper: background citation

Treatment and Prognosis of Neurogenic Orthostatic Hypotension : A Prospective Randomized Study

TypeinterventionalSponsorSeoul National University HospitalRan2014 to 2016Enrolled87ConditionsOrthostatic, Hypotension, NeurogenicArmsMidodrine, Pyridostigmine Bromide, Midodrine + pyridostigmine
NCT02963181 early_phase1terminatednot on this mapstarted 2018, after this paper: background citation

Identifying the Pathophysiology of Neurogenic Orthostatic Hypotension and the Effects of Melatonin on Reducing Supine Hypertension in Peripherally Intact Versus Denervated Post-ganglionic Sympathetic Nerves

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2018 to 2019Enrolled10ConditionsHypotension, Orthostatic, Hypertension, Autonomic Nervous System DiseasesArmsYohimbine, Melatonin
3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Meta-analysis of the safety and efficacy of droxidopa for neurogenic orthostatic hypotension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2016
    Pooled it
  2. Pooled it
  3. Efficacy of atomoxetine versus midodrine for neurogenic orthostatic hypotension.Annals of clinical and translational neurology · 2020
    Trial
  4. Trial
  5. Trial
  6. Article
  7. Review
  8. Review
  9. Article
  10. Aetiology and haemodynamic patterns of orthostatic hypotension in a tertiary syncope unit.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Clinical Assessment of the Autonomic Nervous System.Cardiac electrophysiology clinics · 2024
    Review
  15. Article
  16. A pathophysiological biomarker combination separates Lewy body from non-Lewy body neurogenic orthostatic hypotension ​.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024
    Observational
  17. Article
  18. Tilt-evoked, breathing-driven blood pressure oscillations: Independence from baroreflex-sympathoneural function.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024
    Observational
  19. Article
  20. Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

David S GoldsteinClinical Neurocardiology Section, Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892-1620, USA. goldsteind@ninds.nih.gov
Yehonatan Sharabi

Funding

Biomarkers of Parkinson Disease and Related DisordersZIANS003034 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GOLDSTEIN, DAVID · 2009 to 2025
$22.8M
Biomarkers of Parkinson Disease and Related DisordersZ01NS003034 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI GOLDSTEIN, DAVID · 2007 to 2008
$3.9M
Intramural NIH HHS Z99 NS999999
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AlgorithmsAutonomic Nervous System DiseasesHumansHypotension, OrthostaticNorepinephrinePrevalenceNorepinephrine

Identifiers

PMID19124673
PMCPMC4182314

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.