ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2009
Postmenopausal levels of endogenous sex hormones and risk of colorectal cancer.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Endogenous Circulating Sex Hormone Concentrations and Colon Cancer Risk in Postmenopausal Women: A Prospective Study and Meta-Analysis.JNCI cancer spectrum · 2021Pooled it
- The increased risk of colorectal cancer in the women who underwent hysterectomy from the South Korean National Health Insurance Database.BMC women's health · 2023Article
- Article
- Estrogen concentration and estrogen receptor-β expression in postmenopausal colon cancer considering patient/tumor background.Journal of cancer research and clinical oncology · 2022Article
- Circulating Levels of Testosterone, Sex Hormone Binding Globulin and Colorectal Cancer Risk: Observational and Mendelian Randomization Analyses.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Observational
- An approach to classifying occupational exposures to endocrine disrupting chemicals by sex hormone function using an expert judgment process.Journal of exposure science & environmental epidemiology · 2021Review
- Endogenous Progestogens and Colorectal Cancer Risk among Postmenopausal Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Article
- Endogenous sex steroid hormones and colorectal cancer risk: a systematic review and meta-analysis.Discover oncology · 2021Review
- Plasma sex hormones and risk of conventional and serrated precursors of colorectal cancer in postmenopausal women.BMC medicine · 2021Article
- Endogenous sex hormones and colorectal cancer survival among men and women.International journal of cancer · 2020Article
- Serial endometrial thickness and risk of non-endometrial hormone-dependent cancers in postmenopausal women in UK Collaborative Trial of Ovarian Cancer Screening.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2020Article
- Patients with non-colorectal cancers may be at elevated risk of colorectal neoplasia.Journal of Cancer · 2020Article
- Obesity and the Risk of Gastrointestinal Cancers.Digestive diseases and sciences · 2019Review
- Type 2 diabetes and risk of colorectal cancer in two large U.S. prospective cohorts.British journal of cancer · 2018Article
- Adiposity and gastrointestinal cancers: epidemiology, mechanisms and future directions.Nature reviews. Gastroenterology & hepatology · 2018Review
- Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer.British journal of cancer · 2018Article
- Significance of intratissue estrogen concentration coupled with estrogen receptors levels in colorectal cancer prognosis.Oncotarget · 2017Article
- Estrogen Activation by Steroid Sulfatase Increases Colorectal Cancer Proliferation via GPER.The Journal of clinical endocrinology and metabolism · 2017Article
- Reproductive and menstrual factors and colorectal cancer incidence in the Women's Health Initiative Observational Study.British journal of cancer · 2017Observational
- Menopausal Hormone Therapy, Age, and Chronic Diseases: Perspectives on Statistical Trends.Chemical research in toxicology · 2016Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 4 countries.
Funding
Abstract
Observational epidemiologic studies and randomized trials have reported a protective effect of oral hormonal replacement therapy on risk of colorectal cancer. Only one previous prospective study, the Women's Health Initiative Observational Study, has reported on the relationship between endogenous hormones and incident colorectal cancer. Contrary to expectation, the investigators found that women with higher circulating estradiol levels were at increased risk of developing colorectal cancer. We conducted a case-control study nested within the New York University Women's Health Study prospective cohort to evaluate the association between endogenous levels of estrone, estradiol, and sex hormone-binding globulin (SHBG) with risk of colorectal cancer. We measured hormones and SHBG in serum samples collected at enrollment from a total of 148 women who subsequently developed colorectal cancer and 293 matched controls. Circulating estrone levels were positively associated with risk of colorectal cancer: The odds ratio for the highest versus lowest quartile of estrone was 1.8 (95% confidence interval, 1.0-3.3). We found a nonsignificant inverse association between SHBG and colorectal cancer, which disappeared after adjusting for body mass index. We did not find an association between estradiol and colorectal cancer risk, but we cannot rule out a potential association because of substantial laboratory error in the measurement. Our results suggest that endogenous estrone is associated with increased risk of colorectal cancer in postmenopausal women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.