ArticleThe Journal of biological chemistry2009
Glucocorticoid receptor activation of the Ciz1-Lcn2 locus by long range interactions.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 73 citations in OpenAlex.
- The multimerization pathway of the glucocorticoid receptor.Nucleic acids research · 2025Article
- Emerging Epigenetic and Posttranslational Mechanisms Controlling Resistance to Glucocorticoids in Acute Lymphoblastic Leukemia.HemaSphere · 2023Review
- Myod1 and GR coordinate myofiber-specific transcriptional enhancers.Nucleic acids research · 2021Article
- Hormone-control regions mediate steroid receptor-dependent genome organization.Genome research · 2019Article
- BRG1 governs glucocorticoid receptor interactions with chromatin and pioneer factors across the genome.eLife · 2018Article
- Glucocorticoid Receptor and Adipocyte Biology.Nuclear receptor research · 2018Article
- A long-range flexible billboard model of gene activation.Transcription · 2017Article
- Genomic effects of glucocorticoids.Protoplasma · 2017Review
- The Glucocorticoid Receptor Regulates the ANGPTL4 Gene in a CTCF-Mediated Chromatin Context in Human Hepatic Cells.PloS one · 2017Article
- Capture-C reveals preformed chromatin interactions between HIF-binding sites and distant promoters.EMBO reports · 2016Article
- SETDB2 Links Glucocorticoid to Lipid Metabolism through Insig2a Regulation.Cell metabolism · 2016Article
- Transcriptional regulation of FoxO3 gene by glucocorticoids in murine myotubes.American journal of physiology. Endocrinology and metabolism · 2016Article
- The Role of Cdkn1A-Interacting Zinc Finger Protein 1 (CIZ1) in DNA Replication and Pathophysiology.International journal of molecular sciences · 2016Review
- Stress and glucocorticoid receptor transcriptional programming in time and space: Implications for the brain-gut axis.Neurogastroenterology and motility · 2016Review
- Novel aspects of glucocorticoid actions.Journal of neuroendocrinology · 2014Review
- Promoter-bound p300 complexes facilitate post-mitotic transmission of transcriptional memory.PloS one · 2014Article
- Altered gene expression patterns in muscle ring finger 1 null mice during denervation- and dexamethasone-induced muscle atrophy.Physiological genomics · 2013Article
- Complex genomic interactions in the dynamic regulation of transcription by the glucocorticoid receptor.Molecular and cellular endocrinology · 2013Review
- Chromatin architecture defines the glucocorticoid response.Molecular and cellular endocrinology · 2013Review
- Regulation of hypothalamic corticotropin-releasing hormone transcription by elevated glucocorticoids.Molecular endocrinology (Baltimore, Md.) · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The cellular response to glucocorticoid receptor (GR) activation involves a highly orchestrated series of regulatory actions influenced at multiple levels by a variety of mechanisms including the action of transcription factors and chromatin modifiers. Because the majority of GR binding sites (glucocorticoid-responsive elements (GREs)) are distant from promoters, it is likely that interactions at a distance play an important role in GR action. To determine whether long range chromosomal associations play a role in transcription regulation by GR, we utilized a chromosome conformation capture-based technique (associated chromosome trap) to identify unknown, remote sequences that interact with the GR-induced Lipocalin2 (Lcn2) gene. Our screen revealed that the Lcn2 GRE interacts with the Ciz1 gene, nearly 30 kb upstream. Ciz1 was subsequently found to be a novel GR-responsive gene. The GRE proximal to the Lcn2 promoter apparently functions to regulate both the Lcn2 gene and the distal Ciz1 gene. Using quantitative chromosome conformation capture, we find that a loop structure is organized between these two genes. This structure is hormone-independent and present only in cell types where the genes are active. The strong correlation between gene expression and loop structure in different cell lines suggests that high order interactions play a role in determining tissue-specific gene regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.