ReviewTherapeutic advances in cardiovascular disease2008
Systemic and uteroplacental renin--angiotensin system in normal and pre-eclamptic pregnancies.
Review in Therapeutic advances in cardiovascular disease, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- COVID-19 and miscarriage: From immunopathological mechanisms to actual clinical evidence.Journal of reproductive immunology · 2021Pooled it
- Associations of ACE I/D, AGT M235T gene polymorphisms with pregnancy induced hypertension in Chinese population: a meta-analysis.Journal of assisted reproduction and genetics · 2012Pooled it
- Reducing stillbirths: prevention and management of medical disorders and infections during pregnancy.BMC pregnancy and childbirth · 2009Pooled it
- Corpus luteum number and the maternal renin-angiotensin-aldosterone system as determinants of utero-placental (vascular) development: the Rotterdam Periconceptional Cohort.Reproductive biology and endocrinology : RB&E · 2021Trial
- Different effects of tocolytic medication on blood pressure and blood pressure amplification.European journal of clinical pharmacology · 2011Trial
- Maternal kidney adaptation and function in pregnancy: review and perspectives.Function (Oxford, England) · 2026Review
- Second Trimester Amniotic Fluid Angiotensinogen Levels Linked to Increased Fetal Birth Weight and Shorter Gestational Age in Term Pregnancies.Life (Basel, Switzerland) · 2024Article
- Targeting the apelin system for the treatment of cardiovascular diseases.Cardiovascular research · 2023Review
- Cardiovascular Dysfunction in Intrauterine Growth Restriction.Current hypertension reports · 2022Review
- SARS-CoV-2 (COVID-19) as a possible risk factor for neurodevelopmental disorders.Frontiers in neuroscience · 2022Review
- A Narrative Review of the Renin-Angiotensin-Aldosterone System in the Placenta and Placental Bed of HIV Infected Women of African Ancestry with Preeclampsia.Current hypertension reports · 2021Review
- Megalin, Proton Pump Inhibitors and the Renin-Angiotensin System in Healthy and Pre-Eclamptic Placentas.International journal of molecular sciences · 2021Article
- Endometrial gene expression profiling of recurrent implantation failure after in vitro fertilization.Molecular biology reports · 2021Article
- Maternal endothelial dysfunction in HIV-associated preeclampsia comorbid with COVID-19: a review.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Review
- RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models.The Journal of clinical investigation · 2020Article
- Intrauterine Inflammation Alters the Transcriptome and Metabolome in Placenta.Frontiers in physiology · 2020Article
- Potential Marker Pathways in the Endometrium That May Cause Recurrent Implantation Failure.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Maternal Venous Hemodynamic Dysfunction in Proteinuric Gestational Hypertension: Evidence and Implications.Journal of clinical medicine · 2019Review
- Pregnancy upregulates angiotensin type 2 receptor expression and increases blood flow in uterine arteries of rats.Biology of reproduction · 2018Article
- Candidate Gene, Genome-Wide Association and Bioinformatic Studies in Pre-eclampsia: a Review.Current hypertension reports · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Pregnancy is characterized by an increase in many of the different components of the circulating renin-angiotensin system (RAS). However, the physiological mechanisms of stimulated RAS activity during pregnancy are unknown. Even less understood is how this system may be altered in pre-eclampsia, a hypertensive disorder of pregnancy. Additional studies have shown the presence of a local tissue specific RAS in the uteroplacental unit of normal and pre-eclamptic pregnancies. Differences in normal pregnant and pre-eclamptic RAS component regulation may provide insight into the mechanisms responsible for the clinical pathological features of pre-eclampsia. Specifically, this review summarizes the key findings in the circulating and uteroplacental RAS in normal and pre-eclamptic pregnancies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.