Evidence map›Paper›PMID 19124428›Full record

ReviewTherapeutic advances in cardiovascular disease2008

Stroke prevention: modifying risk factors.

José Rafael Romero, Jane Morris, Aleksandra Pikula

Open access · greenAbstract readReview
In one paragraph

Review in Therapeutic advances in cardiovascular disease, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Review
  8. Artificial intelligence and atrial fibrillation.Journal of cardiovascular electrophysiology · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. The Nrf2 Pathway in Ischemic Stroke: A Review.Molecules (Basel, Switzerland) · 2021
    Review
  13. Article
  14. Article
  15. Review
  16. Lipid Emulsion Improves Functional Recovery in an Animal Model of Stroke.International journal of molecular sciences · 2020
    Article
  17. Prevalence of the prothrombin G20210A mutation among ischemic stroke patients.Journal of cardiovascular and thoracic research · 2020
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

José Rafael RomeroDepartment of Neurology, Boston University School of Medicine, Boston, MA 02118, USA. joromero@bmc.org
Jane Morris
Aleksandra Pikula
Boston Medical Center · USBoston University · USUniversity of Massachusetts Chan Medical School · US

Funding

PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4M
MRI, Genetics &Cognitive Precursors of AD &DementiaR01AG016495 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 1999 to 2016
$12.5M
Ventricular Matrix Remodeling: Correlates and PrognosisR01HL067288 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S. · 2001 to 2004
$870k
ASYMPTOMATIC LEFT VENTRICULAR DYSFUNCTIONK24HL004334 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2001 to 2008
$707k
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
NHLBI NIH HHS 2K24HL04334NHLBI NIH HHS HL67288NHLBI NIH HHS K24 HL004334NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01-HC-25195NHLBI NIH HHS R01 HL067288NIA NIH HHS AG08122NIA NIH HHS AG16495NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG016495NINDS NIH HHS NS17950NINDS NIH HHS R01 NS017950
6 · The paper itself

Abstract

Risk factor modification remains as the principal aspect of care for stroke prevention. Understanding of risk factors has advanced and several options are now available to treat modifiable risk factors. However, effective treatment remains a challenging task in clinical practice. Prevention begins with awareness of risk factors by patients and clinicians. Risk factor assessment along with overall stroke risk estimation should be part of evaluation of patients with stroke, and used with careful clinical judgment. In this review, we discuss the impact of modifiable traditional vascular risk factors on ischemic stroke, interventions for stroke prevention, and evidence for early treatment of risk factors where available, as well as areas of research progress. Emphasis should be put on the education of patients, the community, and medical personnel. Future research in the field of genetic determinants of vascular risk factors and stroke will increase our understanding of the underlying mechanisms of cerebrovascular disease and likely result in development of new therapies and individualized programs for stroke prevention.

Indexed as

Atrial FibrillationCarotid Artery DiseasesDiabetes ComplicationsHumansHyperlipidemiasHypertensionObesityRisk AssessmentRisk FactorsSmokingSmoking CessationSmoking PreventionStroke

Identifiers

PMID19124428
PMCPMC2729177
OpenAlexW1748399218

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.