ArticlePituitary2011
Primary CNS lymphoma with bilateral symmetric hypothalamic lesions presenting with panhypopituitarism and diabetes insipidus.
Article in Pituitary, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- Primary central nervous system lymphoma: A mirror type presentation in an immunocompetent patient.Surgical neurology international · 2024Article
- Primary hypothalamic lymphoma with clinical findings mimicking pituitary apoplexy: a case report.Journal of medical case reports · 2021Article
- External-Beam Radiotherapy Alone Management of Primary CNS Lymphoplasmacytic Lymphoma: A Vietnamese Case Report and Literature Review.Journal of blood medicine · 2021Article
- Primary central nervous system lymphoma involving the hypothalamic-pituitary axis: a case series and pooled analysis.Journal of neuro-oncology · 2020Article
- Neuroimaging of central diabetes insipidus-when, how and findings.Neuroradiology · 2018Review
- Primary Hypothalamic Lymphoma in an Adult Male: A Case Report and Literature Review.Oman medical journal · 2018Article
- Restored vision in a young dog following corticosteroid treatment of presumptive hypophysitis.BMC veterinary research · 2017Article
- Hypothalamic dysfunction in a patient with primary lymphoma of the central nervous system.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2012Article
- Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We present an unusual case of primary central nervous system (CNS) lymphoma presenting with bilateral symmetric hypothalamic lesions causing diabetes insipidus and hypopituitarism. A 50-year-old male presented initially with mental status changes, polyuria and polydipsia. The patient was determined to have diabetes insipidus (DI) and significant anterior pituitary deficiencies resulting in symptomatic pleural and pericardial effusions. Brain MRI with contrast demonstrated bilateral enhancement of his hypothalamus extending to the optic tract. The extensive diagnostic workup that ensued on his initial presentation was non-diagnostic as he had no obvious site of involvement that was easily accessible to biopsy. With close follow-up, the patient had rapid radiographic progression of his disease to his cerebral hemispheres. He therefore underwent brain biopsy and was diagnosed with primary CNS large B cell lymphoma. Chemotherapy has resulted in disease remission with resolution of MRI findings, but the patient has not had resolution of the hypopituitarism or DI. This case highlights the unique diagnostic challenge of patients with isolated hypothalamic lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.