ArticleMammalian genome : official journal of the International Mammalian Genome Society2009
Polymorphism in hybrid male sterility in wild-derived Mus musculus musculus strains on proximal chromosome 17.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Beyond the Prdm9 model: independent evolution of hybrid male sterility in house mice.Heredity · 2026Article
- Phenogenomic resources immortalized in a panel of wild-derived strains of five species of house mice.Scientific reports · 2025Article
- A Minimal Hybrid Sterility Genome Assembled by Chromosome Swapping Between Mouse Subspecies (Mus musculus).Molecular biology and evolution · 2024Article
- Meiotic Recognition of Evolutionarily Diverged Homologs: Chromosomal Hybrid Sterility Revisited.Molecular biology and evolution · 2023Article
- The contribution of sex chromosome conflict to disrupted spermatogenesis in hybrid house mice.Genetics · 2022Article
- Genic and chromosomal components of Prdm9-driven hybrid male sterility in mice (Mus musculus).Genetics · 2022Article
- Prdm9 Intersubspecific Interactions in Hybrid Male Sterility of House Mouse.Molecular biology and evolution · 2020Article
- Variable hybridization outcomes in trout are predicted by historical fish stocking and environmental context.Molecular ecology · 2019Article
- Phenotypic effects of the Y chromosome are variable and structured in hybrids among house mouse recombinant lines.Ecology and evolution · 2019Article
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- Genetic vs environment influences on house mouse hybrid zone in Iran.Journal, genetic engineering & biotechnology · 2017Article
- Gene regulation and speciation in house mice.Genome research · 2016Article
- The Pace of Hybrid Incompatibility Evolution in House Mice.Genetics · 2015Article
- Speciation and reduced hybrid female fertility in house mice.Evolution; international journal of organic evolution · 2015Article
- A Cascade of epistatic interactions regulating teratozoospermia in mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Functional organization of the genome may shape the species boundary in the house mouse.Molecular biology and evolution · 2015Article
- Contrasting patterns of polymorphism and selection in bacterial-sensing toll-like receptor 4 in two house mouse subspecies.Ecology and evolution · 2014Article
- The uncharacterized gene 1700093K21Rik and flanking regions are correlated with reproductive isolation in the house mouse, Mus musculus.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Article
- X chromosome control of meiotic chromosome synapsis in mouse inter-subspecific hybrids.PLoS genetics · 2014Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The hybrid sterility-1 (Hst1) locus at Chr 17 causes male sterility in crosses between the house mouse subspecies Mus musculus domesticus (Mmd) and M. m. musculus (Mmm). This locus has been defined by its polymorphic variants in two laboratory strains (Mmd genome) when mated to PWD/Ph mice (Mmm genome): C57BL/10 (carrying the sterile allele) and C3H (fertile allele). The occurrence of sterile and/or fertile (wild Mmm x C57BL)F1 males is evidence that polymorphism for this trait also exists in natural populations of Mmm; however, the nature of this polymorphism remains unclear. Therefore, we derived two wild-origin Mmm strains, STUS and STUF, that produce sterile and fertile males, respectively, in crosses with C57BL mice. To determine the genetic basis underlying male fertility, the (STUS x STUF)F1 females were mated to C57BL/10 J males. About one-third of resulting hybrid males (33.8%) had a significantly smaller epididymis and testes than parental animals and lacked spermatozoa due to meiotic arrest. A further one-fifth of males (20.3%) also had anomalous reproductive traits but produced some spermatozoa. The remaining fertile males (45.9%) displayed no deviation from values found in parental individuals. QTL analysis of the progeny revealed strong associations of male fitness components with the proximal end of Chr 17, and a significant effect of the central section of Chr X on testes mass. The data suggest that genetic incompatibilities associated with male sterility have evolved independently at the proximal end of Chr 17 and are polymorphic within both Mmd and Mmm genomes.
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