ArticleCurrent microbiology2009
Transformation of L-tyrosine to L-dopa by a novel fungus, Acremonium rutilum, under submerged fermentation.
Article in Current microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 69 citations in OpenAlex.
- Heterologous expression of hydroxylase coupled with pathway optimization enables highly efficient ʟ-DOPA production inSynthetic and systems biotechnology · 2026Article
- Efficient synthesis of l-DOPA inSynthetic and systems biotechnology · 2026Article
- Maximizing dopa-oxidase activity in Aspergillus oryzae mycelia: insights into production optimization and potential biomedical applications.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Scaling up production of cephalosporin C by Acremonium chrysogenum W42-I in a fermenter using submerged fermentation.AMB Express · 2024Article
- Immobilization of Aspergillus oryzae tyrosine hydroxylase on ZnO nanocrystals for improved stability and catalytic efficiency towards L-dopa production.Scientific reports · 2023Article
- Rapid production of l-DOPA by Vibrio natriegens, an emerging next-generation whole-cell catalysis chassis.Microbial biotechnology · 2022Article
- Tyrosinase-based production of L-DOPA by Corynebacterium glutamicum.Applied microbiology and biotechnology · 2021Article
- Equine grass sickness (a multiple systems neuropathy) is associated with alterations in the gastrointestinal mycobiome.Animal microbiome · 2021Article
- Integrating enzyme evolution and high-throughput screening for efficient biosynthesis of L-DOPA.Journal of industrial microbiology & biotechnology · 2019Article
- Potential of Aqueous Two-Phase Systems for the Separation of Levodopa from Similar Biomolecules.Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986) · 2018Article
- Nutraceuticals in Parkinson's Disease.Neuromolecular medicine · 2016Review
- Genome engineering Escherichia coli for L-DOPA overproduction from glucose.Scientific reports · 2016Article
- Evaluation of Various Factors Affecting Bioconversion of l-Tyrosine to l-DOPA by Yeast Yarrowia lipolytica-NCIM 3450 Using Response Surface Methodology.Natural products and bioprospecting · 2014Article
- Microbial tyrosinases: promising enzymes for pharmaceutical, food bioprocessing, and environmental industry.Biochemistry research international · 2014Review
- Actinobacterial melanins: current status and perspective for the future.World journal of microbiology & biotechnology · 2013Review
- Metabolic potential of the organic-solvent tolerant Pseudomonas putida DOT-T1E deduced from its annotated genome.Microbial biotechnology · 2013Article
- Optimization of Biotransformation of l-Tyrosine to l-DOPA by Yarrowia lipolytica-NCIM 3472 Using Response Surface Methodology.Indian journal of microbiology · 2013Article
- Statistically optimized biotransformation protocol for continuous production of L-DOPA using Mucuna monosperma callus culture.SpringerPlus · 2013Article
- Optimization of L-DOPA production by Brevundimonas sp. SGJ using response surface methodology.Microbial biotechnology · 2012Article
- Metabolic engineering of Escherichia coli for improving L-3,4-dihydroxyphenylalanine (L-DOPA) synthesis from glucose.Journal of industrial microbiology & biotechnology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study deals with the transformation of L-tyrosine to L-dopa by Acremonium rutilum, a fungal tyrosinase producer, isolated from decomposed banana stud. This appears to be the first report on A. rutilum as a polyphenoloxidase producer with both cresolase and catecholase activity. Enriched Czapek-Dox agar was used for plate assay screening. Enriched potato dextrose broth was used for optimization studies, which induced high levels of L-dopa under submerged fermentation. A. rutilum gave the maximum L-dopa production (0.89 mg/ml) and tyrosinase activity (1095 U/mg) under the optimized parameters, that is, a temperature of 25 degrees C, pH 5.5, an inoculum size of 2.5 ml, and an incubation time of 72-120 h, with L-tyrosine (5 mg/ml) as substrate. Five resolved bands, with R(f) values of 0.73, 0.60, 0.54, 0.37, and 0.26, were observed, which confirmed the presence of L-dopa. This study involves the elevated profile of L-dopa production. Such study is needed, as L-dopa has the ability to control Parkinson's disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.