ArticleComputational and mathematical methods in medicine2008
Irregular and Semi-Regular Polyhedral Models for Rous Sarcoma Virus Cores.
Article in Computational and mathematical methods in medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- High resolution electron tomography and segmentation-by-modeling interpretation in Bsoft.Protein science : a publication of the Protein Society · 2021Article
- In vitro assembly of the Rous Sarcoma Virus capsid protein into hexamer tubes at physiological temperature.Scientific reports · 2017Article
- Article
- Potential role for CA-SP in nucleating retroviral capsid maturation.Journal of virology · 2014Article
- Capturing enveloped viruses on affinity grids for downstream cryo-electron microscopy applications.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2014Article
- A two-pronged structural analysis of retroviral maturation indicates that core formation proceeds by a disassembly-reassembly pathway rather than a displacive transition.Journal of virology · 2013Article
- Clathrin-coated vesicles from brain have small payloads: a cryo-electron tomographic study.Journal of structural biology · 2013Article
- Article
- Assembly and architecture of HIV.Advances in experimental medicine and biology · 2012Review
- Design of in vitro symmetric complexes and analysis by hybrid methods reveal mechanisms of HIV capsid assembly.Journal of molecular biology · 2011Article
- HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice.Journal of virology · 2011Article
- Atomic-level modelling of the HIV capsid.Nature · 2011Article
- Hexagonal assembly of a restricting TRIM5alpha protein.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Suppression of a morphogenic mutant in Rous sarcoma virus capsid protein by a second-site mutation: a cryoelectron tomography study.Journal of virology · 2010Article
- The structure of elongated viral capsids.Biophysical journal · 2010Article
- Proton-driven assembly of the Rous Sarcoma virus capsid protein results in the formation of icosahedral particles.The Journal of biological chemistry · 2010Article
- Article
- Retroviral capsid assembly: a role for the CA dimer in initiation.Journal of molecular biology · 2009Article
- Article
- Morphology and ultrastructure of retrovirus particles.AIMS biophysicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Whereas many viruses have capsids of uniquely defined sizes that observe icosahedral symmetry, retrovirus capsids are highly polymorphic. Nevertheless, they may also be described as polyhedral foldings of a fullerene lattice on which the capsid protein (CA) is arrayed. Lacking the high order of symmetry that facilitates the reconstruction of icosahedral capsids from cryo-electron micrographs, the three-dimensional structures of individual retrovirus capsids may be determined by cryo-electron tomography, albeit at lower resolution. Here we describe computational and graphical methods to construct polyhedral models that match in size and shape, capsids of Rous sarcoma virus (RSV) observed within intact virions [8]. The capsids fall into several shape classes, including tubes, "lozenges", and "coffins". The extent to which a capsid departs from icosahedral symmetry reflects the irregularity of the distribution of pentamers, which are always 12 in number for a closed polyhedral capsid. The number of geometrically distinct polyhedra grows rapidly with increasing quotas of hexamers, and ranks in the millions for RSV capsids, which typically have 150 - 300 hexamers. Unlike the capsid proteins of icosahedral viruses that assume a minimal number of quasi-equivalent conformations equal to the triangulation number (T), retroviral CAs exhibit a near-continuum of quasi-equivalent conformations - a property that may be attributed to the flexible hinge linking the N- and C-terminal domains.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.