ArticleTransfusion alternatives in transfusion medicine : TATM2008
Blood viscosity modulates tissue perfusion: sometimes and somewhere.
Article in Transfusion alternatives in transfusion medicine : TATM, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Transfusion strategies in non-bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine.Intensive care medicine · 2020Guideline
- Microcirculatory effects of the transfusion of leukodepleted or non-leukodepleted red blood cells in patients with sepsis: a pilot study.Critical care (London, England) · 2014Trial
- [Packed red blood cells-Avoidable risks and complications].Die Anaesthesiologie · 2026Review
- Cognitive functions in schizophrenia: the interplay between blood viscosity, serum osmolarity, and symptom severity.BMC psychiatry · 2025Article
- Microfluidic Chip for Quantitatively Assessing Hemorheological Parameters.Micromachines · 2025Article
- Association between diastolic blood viscosity and functional outcomes after acute ischemic stroke.Clinical hypertension · 2025Article
- Pulse oximetry in pediatric care: Balancing advantages and limitations.World journal of clinical pediatrics · 2024Article
- Clinical analysis of factors affecting the failure of free flaps used in head and neck reconstruction.Archives of craniofacial surgery · 2023Article
- Hyperviscosity syndrome in COVID-19 and related vaccines: exploring of uncertainties.Clinical and experimental medicine · 2023Review
- Blood viscosity associated with stroke mechanism and early neurological deterioration in middle cerebral artery atherosclerosis.Scientific reports · 2023Article
- Changes in the Blood Viscosity in Patients With SARS-CoV-2 Infection.Frontiers in medicine · 2022Review
- Association between blood viscosity and early neurological deterioration in lacunar infarction.Frontiers in neurology · 2022Article
- Tetralogy of Fallot with concurrent patent foramen ovale and tricuspid valve dysplasia in a dog.The Canadian veterinary journal = La revue veterinaire canadienne · 2018Article
- Spatio-temporal simulation of first pass drug perfusion in the liver.PLoS computational biology · 2014Article
- Proposed toxic and hypoxic impairment of a brainstem locus in autism.International journal of environmental research and public health · 2013Article
- Blood viscosity as a forgotten factor and its effect on pulmonary flow.Translational respiratory medicine · 2013Article
- Functional Performance of Different Venous Limb Options in Simulated Neonatal/Pediatric Cardiopulmonary Bypass Circuits.Brazilian journal of cardiovascular surgeryArticle
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
Abstract
Each organ possesses specific properties for controlling microvascular perfusion. Such specificity provides an opportunity to design transfusion fluids that target thrombo-embolic or vasospasm-induced ischemia in a particular organ or that optimize overall perfusion from systemic shock. The role of viscosity in the design of these fluids might be underestimated, because viscosity is rarely monitored or considered in critical care decisions. Studies linking viscosity-dependent changes of microvascular perfusion to outcome-relevant data suggest that whole blood viscosity is negligible as a determinant of microvascular perfusion under physiological conditions when autoregulation is effective. Because autoregulation is driven to maintain oxygen supply constant, the organism will compensate for changes in blood viscosity to sustain oxygen delivery. In contrast, under pathological conditions in the brain and elsewhere, increases of overall viscosity should be avoided - including all the situations where vascular autoregulatory mechanisms are inoperative due to ischemia, structural damage or physiologic dysfunction. As latter conditions are not to identify with high certainty, the risks that accompany therapeutic correction of blood viscosity are outweighing the benefits. The ability to bedside monitor blood viscosity and to link changes in viscosity to outcome parameters in various clinical conditions would provide more solid foundation for evidence-based clinical management.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.