ArticleCurrent immunology reviews2007
Heterogeneity in the CD4 T Cell Compartment and the Variability of Neonatal Immune Responsiveness.
Article in Current immunology reviews, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Modeling human immune responses to vaccination in vitro.Trends in immunology · 2024Review
- OVA-PEG-R848 nanocapsules stimulate neonatal conventional and plasmacytoid dendritic cells.Frontiers in pediatrics · 2022Article
- Gut-Lung Axis: Microbial Crosstalk in Pediatric Respiratory Tract Infections.Frontiers in immunology · 2021Review
- Impact of pregravid obesity on maternal and fetal immunity: Fertile grounds for reprogramming.Journal of leukocyte biology · 2019Review
- Transcriptome analysis of immune genes in peripheral blood mononuclear cells of young foals and adult horses.PloS one · 2018Article
- Human perinatal immunity in physiological conditions and during infection.Molecular and cellular pediatrics · 2017Review
- Guidance on the risk assessment of substances present in food intended for infants below 16 weeks of age.EFSA journal. European Food Safety Authority · 2017Article
- Neonatal Group B Streptococcal Disease in Otherwise Healthy Infants: Failure of Specific Neonatal Immune Responses.Frontiers in immunology · 2017Article
- Increasing JAK/STAT Signaling Function of Infant CD4Frontiers in pediatrics · 2017Article
- Ontogeny of early life immunity.Trends in immunology · 2014Review
- Porcine neonatal blood dendritic cells, but not monocytes, are more responsive to TLRs stimulation than their adult counterparts.PloS one · 2013Article
- An overlapping syndrome of allergy and immune deficiency in children.Journal of allergy · 2012Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Over the past decade, it has become clear that T cell immune responses in both murine and human neonates are very heterogeneous, running the gamut from poor or deviant responsiveness to mature, adult-like inflammatory function. How this variability arises is not well understood but there is now a great deal of information suggesting that differences in the T cell compartments in neonates vs adults play important roles. A number of cell types or processes are qualitatively or quantitatively different in the neonate. These include (a) alternate epigenetic programs at the Th2 cytokine locus, (b) enhanced homeostatic proliferation, (c) a relative abundance of fetal-origin cells, (d) a greater representation of recent thymic emigrants, (e) high proportions of potentially self-reactive cells, (f) a developmental delay in the production of regulatory T cells, and (g) cells bearing TCR with limited N region diversity. Different conditions of antigen exposure may lead to different environmental signals that promote the selective responsiveness of one or more of these populations. Therefore, the variability of neonatal responses may be a function of the heterogeneous nature of the responding T cell population. In this review, we will describe these various subpopulations in detail and speculate as to the manner in which they could contribute to the heterogeneity of neonatal immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.