ReviewCurrent opinion in gastroenterology2008
Molecular basis for pancreatitis.
Review in Current opinion in gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- A comprehensive study indicates PRSS1 gene is significantly associated with pancreatitis.International journal of medical sciences · 2013Pooled it
- A safe method for rapid therapeutic pancreatic cooling.iScience · 2024Article
- Early selective enteral feeding in treatment of acute pancreatitis: A case report.World journal of clinical cases · 2024Article
- Article
- Acute Pancreatitis Following Percutaneous Mechanical Thrombectomy of Left Common Iliac Vein.Journal of community hospital internal medicine perspectives · 2023Article
- Emerging Therapies to Prevent Post-ERCP Pancreatitis.Current gastroenterology reports · 2020Review
- Hsp90 regulation affects the treatment of glucocorticoid for pancreatitis-induced lung injury.Molecular and cellular biochemistry · 2018Article
- Differential role of Hedgehog signaling in human pancreatic (patho-) physiology: An up to date review.World journal of gastrointestinal pathophysiology · 2016Review
- Role of histone deacetylases in pancreas: Implications for pathogenesis and therapy.World journal of gastrointestinal oncology · 2015Review
- Novel lipophilic probe for detecting near-membrane reactive oxygen species responses and its application for studies of pancreatic acinar cells: effects of pyocyanin and L-ornithine.Antioxidants & redox signaling · 2015Article
- Antioxidative phytoceuticals to ameliorate pancreatitis in animal models: an answer from nature.World journal of gastroenterology · 2014Review
- Association of CTRC and SPINK1 gene variants with recurrent hospitalizations for pancreatitis or acute abdominal pain in lipoprotein lipase deficiency.Frontiers in genetics · 2014Article
- Clinical efficacy of gabexate mesilate for acute pancreatitis in children.European journal of pediatrics · 2013Article
- Sterile inflammation in the liver and pancreas.Journal of gastroenterology and hepatology · 2013Review
- Animal models for investigating chronic pancreatitis.Fibrogenesis & tissue repair · 2011Article
- The causes and outcome of acute pancreatitis associated with serum lipase >10,000 u/l.Digestive diseases and sciences · 2011Article
- Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death.The Journal of biological chemistry · 2011Article
- Spinal toll like receptor 3 is involved in chronic pancreatitis-induced mechanical allodynia of rat.Molecular pain · 2011Article
- Transcriptional regulation of CXC-ELR chemokines KC and MIP-2 in mouse pancreatic acini.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
- Laboratory models available to study alcohol-induced organ damage and immune variations: choosing the appropriate model.Alcoholism, clinical and experimental research · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
purpose of reviewThis timely review will focus on clinical and basic science studies that have greatly advanced our knowledge of the molecular mechanisms of both acute pancreatitis and chronic pancreatitis over the last year. RECENT
findingsAnimal models of both severe acute pancreatitis and chronic pancreatitis have recently been developed. Several unexpected protective mechanisms, mediated by the protease activated receptor 2 and heat shock protein 70, have been described. A genetic study suggested that polymorphisms in toll-like receptor-4 might affect the risk of developing infections in acute pancreatitis. Studies of chronic pancreatitis have shown that specific neural receptors, transient receptor potential vanilloid subtype 1, mediate pain responses in a model of chronic pancreatitis. The pancreatic zymogen, chymotrypsin C, can degrade pathologically activated trypsin in the acinar cell. Inactivating mutations in chymotrypsin C have been reported to predispose to the development of chronic pancreatitis, especially in those who are prone to alcohol abuse. SUMMARY: The implications of the last year's findings are widespread. Improved animal models of acute pancreatitis and chronic pancreatitis will be critical for performing pilot studies of therapy. A greater understanding of genetic factors and pain responses could lead to potential treatments. This review will first discuss issues related to acute pancreatitis, and then conclude with studies most relevant to chronic disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.