ArticleMolecular genetics and metabolism2009
Transcriptomic and network component analysis of glycerol kinase in skeletal muscle using a mouse model of glycerol kinase deficiency.
Article in Molecular genetics and metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Measurement of glycolysis with heavy water labeling.The Journal of biological chemistry · 2026Article
- Glycerol kinase 5 confers gefitinib resistance through SREBP1/SCD1 signaling pathway.Journal of experimental & clinical cancer research : CR · 2019Article
- Reconstruction of temporal activity of microRNAs from gene expression data in breast cancer cell line.BMC genomics · 2015Article
- Gestational Diabetes Associated with a Novel Mutation (378-379insTT) in the Glycerol Kinase Gene.Molecular genetics and metabolism reports · 2015Article
- Gene Expression Patterns Associated with Peroxisome Proliferator-activated Receptor (PPAR) Signaling in the Longissimus dorsi of Hanwoo (Korean Cattle).Asian-Australasian journal of animal sciences · 2015Article
- Mathematical modeling of the insulin signal transduction pathway for prediction of insulin sensitivity from expression data.Molecular genetics and metabolism · 2015Article
- Determining PTEN functional status by network component deduced transcription factor activities.PloS one · 2012Article
- Moonlighting function of glycerol kinase causes systems-level changes in rat hepatoma cells.Metabolic engineering · 2010Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Glycerol kinase (GK) is at the interface of fat and carbohydrate metabolism and has been linked to obesity and type 2 diabetes mellitus (T2DM). The purpose of this study was to investigate the role of GK in fat metabolism and insulin signaling in skeletal muscle (an important end organ tissue in T2DM). Microarray analysis determined that there were 525 genes that were differentially expressed (1.2-fold, p value<0.05) between knockout (KO) and wild-type (WT) mice. Quantitative PCR (qPCR) confirmed the differential expression of genes including glycerol kinase (Gyk), phosphatidylinositol 3-kinase regulatory subunit, polypeptide 1 (p85 alpha) (Pik3r1), insulin-like growth factor 1 (Igf1), and growth factor receptor bound protein 2-associated protein 1 (Gab1). Network component analysis demonstrated that transcription factor activities of myogenic differentiation 1 (MYOD), myogenic regulatory factor 5 (MYF5), myogenin (MYOG), nuclear receptor subfamily 4, group A, member 1 (NUR77) are decreased in the Gyk KO whereas the activity of paired box 3 (PAX3) is increased. The activity of MYOD was confirmed using a DNA binding assay. In addition, myoblasts from Gyk KO had less ability to differentiate into myotubes compared to WT myoblasts. These findings support our previous studies in brown adipose tissue and demonstrate that the role of Gyk in muscle is due in part to its non-metabolic (moonlighting) activities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.