ReviewRegulatory toxicology and pharmacology : RTP2009
Structural analysis of linear and conformational epitopes of allergens.
Review in Regulatory toxicology and pharmacology : RTP, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- DHFR2 RNA directly regulates dihydrofolate reductase and its expression level impacts folate one carbon metabolism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- The updated Structural Database of Allergenic Proteins (SDAP 2.0) provides 3D models for allergens and incorporated bioinformatics tools.The journal of allergy and clinical immunology. Global · 2023Article
- Still SDAPing Along: 20 Years of the Structural Database of Allergenic Proteins.Frontiers in allergy · 2022Article
- The importance of the 2S albumins for allergenicity and cross-reactivity of peanuts, tree nuts, and sesame seeds.The Journal of allergy and clinical immunology · 2021Review
- D-graph clusters flaviviruses and β-coronaviruses according to their hosts, disease type and human cell receptors.bioRxiv : the preprint server for biology · 2020Article
- Distinguishing allergens from non-allergenic homologues using Physical-Chemical Property (PCP) motifs.Molecular immunology · 2018Article
- Functional classification of protein toxins as a basis for bioinformatic screening.Scientific reports · 2017Article
- Cross-React: a new structural bioinformatics method for predicting allergen cross-reactivity.Bioinformatics (Oxford, England) · 2017Article
- Article
- Assessment of 3D models for allergen research.Proteins · 2013Article
- Effects of autoclaving and high pressure on allergenicity of hazelnut proteins.Journal of clinical bioinformatics · 2012Article
- Article
- Identification of critical amino acids in an immunodominant IgE epitope of Pen c 13, a major allergen from Penicillium citrinum.PloS one · 2012Article
- AllerML: markup language for allergens.Regulatory toxicology and pharmacology : RTP · 2011Article
- An Allergen Portrait Gallery: Representative Structures and an Overview of IgE Binding Surfaces.Bioinformatics and biology insights · 2010Article
- Food safety.Clinical reviews in allergy & immunology · 2010Review
- Characterization of potential allergens in fenugreek (Trigonella foenum-graecum) using patient sera and MS-based proteomic analysis.Journal of proteomics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
In many countries regulatory agencies have adopted safety guidelines, based on bioinformatics rules from the WHO/FAO and EFSA recommendations, to prevent potentially allergenic novel foods or agricultural products from reaching consumers. We created the Structural Database of Allergenic Proteins (SDAP, http://fermi.utmb.edu/SDAP/) to combine data that had previously been available only as flat files on Web pages or in the literature. SDAP was designed to be user friendly, to be of maximum use to regulatory agencies, clinicians, as well as to scientists interested in assessing the potential allergenic risk of a protein. We developed methods, unique to SDAP, to compare the physicochemical properties of discrete areas of allergenic proteins to known IgE epitopes. We developed a new similarity measure, the property distance (PD) value that can be used to detect related segments in allergens with clinical observed cross-reactivity. We have now expanded this work to obtain experimental validation of the PD index as a quantitative predictor of IgE cross-reactivity, by designing peptide variants with predetermined PD scores relative to known IgE epitopes. In complementary work we show how sequence motifs characteristic of allergenic proteins in protein families can be used as fingerprints for allergenicity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.