Evidence map›Paper›PMID 19121586›Full record

ReviewCytokine2009

miRNA regulation of cytokine genes.

Ananthi J Asirvatham, William J Magner, Thomas B Tomasi

Open access · greenAbstract readReview
In one paragraph

Review in Cytokine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 156 citations in OpenAlex.

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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ananthi J AsirvathamRoswell Park Cancer Institute, Laboratory of Molecular Medicine, Department of Immunology, Elm & Carlton Streets, Buffalo, NY 14263, USA.
William J Magner
Thomas B Tomasi
Roswell Park Comprehensive Cancer Center · US

Funding

STUDIES OF MATERNAL AND NEONATAL IMMUNITYR01HD017013 · NICHD · UNIVERSITY OF NEW MEXICO · PI TOMASI, THOMAS B · 1985 to 2006
$2.5M
Epigenetic Regulation of Immune Genes in Cancer Treatment and Vaccine ProtocolsR01CA124971 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI TOMASI, THOMAS B · 2008 to 2011
$1.3M
NCI NIH HHS CA 124971NCI NIH HHS R01 CA124971NICHD NIH HHS HD 17013NICHD NIH HHS R01 HD017013
6 · The paper itself

Abstract

In this review we discuss specific examples of regulation of cytokine genes and focus on a new mechanism involving post-transcriptional regulation via miRNAs. The post-transcriptional regulation of cytokine genes via the destabilizing activity of AU-rich elements [AREs] and miRNAs is a pre-requisite for regulating the half-life of many cytokines and achieving the temporal and spatial distributions required for regulation of these genes.

Indexed as

Gene Expression RegulationMicroRNAsAnimalsCytokinesEvolution, MolecularHumansImmunity, InnateInflammationNeoplasmsRNA Processing, Post-TranscriptionalTranscription FactorsCytokinesMicroRNAsTranscription Factors

Identifiers

PMID19121586
PMCPMC3129852
OpenAlexW2001866502

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.