ArticleEuropean journal of cancer (Oxford, England : 1990)2009
Stat3 activation is required for the growth of U87 cell-derived tumours in mice.
Article in European journal of cancer (Oxford, England : 1990), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 38 citations in OpenAlex.
- Three Thiol-Reactive Reagents drive Synergistic Lethality in Glioblastoma cells.Research square · 2026Article
- Targeted siRNA Delivery by Bioinspired Cancer Cell Membrane-Coated Nanoparticles with Enhanced Anti-Cancer Immunity.International journal of nanomedicine · 2023Article
- Potential Therapeutic Effects of Thiazolidinedione on Malignant Glioma.International journal of molecular sciences · 2022Article
- Transcription Factors with Targeting Potential in Gliomas.International journal of molecular sciences · 2022Review
- Therapeutic Targeting of Stat3 Using Lipopolyplex Nanoparticle-Formulated siRNA in a Syngeneic Orthotopic Mouse Glioma Model.Cancers · 2019Article
- Sirtuin 7 promotes glioma proliferation and invasion through activation of the ERK/STAT3 signaling pathway.Oncology letters · 2019Article
- miR-519a enhances chemosensitivity and promotes autophagy in glioblastoma by targeting STAT3/Bcl2 signaling pathway.Journal of hematology & oncology · 2018Article
- Review
- Role of STAT3 in Genesis and Progression of Human Malignant Gliomas.Molecular neurobiology · 2017Review
- TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3.Molecular oncology · 2017Article
- Lumbar puncture-administered resveratrol inhibits STAT3 activation, enhancing autophagy and apoptosis in orthotopic rat glioblastomas.Oncotarget · 2016Article
- MiR-519a functions as a tumor suppressor in glioma by targeting the oncogenic STAT3 pathway.Journal of neuro-oncology · 2016Article
- Knockdown of PKCε expression inhibits growth, induces apoptosis and decreases invasiveness of human glioma cells partially through Stat3.Journal of molecular neuroscience : MN · 2015Article
- STAT3 Tyr705 phosphorylation affects clinical outcome in patients with newly diagnosed supratentorial glioblastoma.Medical oncology (Northwood, London, England) · 2014Article
- STAT3 serine 727 phosphorylation influences clinical outcome in glioblastoma.International journal of clinical and experimental pathology · 2014Article
- iNOS: a potential therapeutic target for malignant glioma.Current molecular medicine · 2013Review
- Critical analysis of the potential for targeting STAT3 in human malignancy.OncoTargets and therapy · 2013Article
- The role of microglia and matrix metalloproteinases involvement in neuroinflammation and gliomas.Clinical & developmental immunology · 2013Review
- The molecular profile of microglia under the influence of glioma.Neuro-oncology · 2012Review
- Induction of cell-cycle arrest and apoptosis in glioblastoma stem-like cells by WP1193, a novel small molecule inhibitor of the JAK2/STAT3 pathway.Journal of neuro-oncology · 2012Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Previously we reported that Stat3 is persistently activated in GBM tumours and derived cell lines. Hypoxia, necrosis and neo-angiogenesis are hallmarks of GBM. To unfold the contribution of activated Stat3 to the growth of GBM, we generated human GBM cell line (U87)-derived stable clones expressing a dominant negative mutant (DN)-Stat3 in a hypoxia-inducible manner, and examined their tumour-forming potentials in immune-compromised mice. We found that the parental and vector control cell-derived tumours grew steadily, whereas DN-Stat3-expressing clone-derived tumours failed to grow beyond 2mm of thickness in mouse flanks. This blockade of tumour growth was associated with induction of tumour cell apoptosis and suppression of tumour angiogenesis. Consistent with this, mice bearing orthotopically implanted DN-Stat3-expressing clones survived significantly longer than the control mice. These data suggest that activated Stat3 is required for the growth of GBM, and that targeting Stat3 may intervene with the growth of GBM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.