ArticleDevelopmental biology2009
Morphogenetic movements driving neural tube closure in Xenopus require myosin IIB.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 94 citations in OpenAlex.
- Mechanical control of neural plate folding by apical domain alteration.Nature communications · 2023Article
- Direct investigation of cell contraction signal networks by light-based perturbation methods.Pflugers Archiv : European journal of physiology · 2023Review
- Glycolytic activity is required for the onset of neural plate folding during neural tube closure in mouse embryos.Frontiers in cell and developmental biology · 2023Article
- Cellular mechanisms of reverse epithelial curvature in tissue morphogenesis.Frontiers in cell and developmental biology · 2022Review
- Neural tube defects: Different types and brief review of neurulation process and its clinical implication.Journal of family medicine and primary care · 2021Review
- Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion.Nature communications · 2021Article
- Mechanical feedback and robustness of apical constrictions in Drosophila embryo ventral furrow formation.PLoS computational biology · 2021Article
- Hallmarks of primary neurulation are conserved in the zebrafish forebrain.Communications biology · 2021Article
- Convergent extension in mammalian morphogenesis.Seminars in cell & developmental biology · 2020Review
- Tissue mechanics drives regeneration of a mucociliated epidermis on the surface of Xenopus embryonic aggregates.Nature communications · 2020Article
- Functional Validation ofFrontiers in neuroscience · 2020Article
- Intestinal Morphogenesis in Development, Regeneration, and Disease: The Potential Utility of Intestinal Organoids for Studying Compartmentalization of the Crypt-Villus Structure.Frontiers in cell and developmental biology · 2020Review
- Cdh2 coordinates Myosin-II dependent internalisation of the zebrafish neural plate.Scientific reports · 2019Article
- Emergent mechanics of actomyosin drive punctuated contractions and shape network morphology in the cell cortex.PLoS computational biology · 2018Article
- The Ajuba family protein Wtip regulates actomyosin contractility during vertebrate neural tube closure.Journal of cell science · 2018Article
- Morphogenesis and Compartmentalization of the Intestinal Crypt.Developmental cell · 2018Article
- Article
- Biomechanical coupling facilitates spinal neural tube closure in mouse embryos.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Neural tube closure: cellular, molecular and biomechanical mechanisms.Development (Cambridge, England) · 2017Review
- Fetal DNA hypermethylation in tight junction pathway is associated with neural tube defects: A genome-wide DNA methylation analysis.Epigenetics · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Vertebrate neural tube formation involves two distinct morphogenetic events--convergent extension (CE) driven by mediolateral cell intercalation, and bending of the neural plate driven largely by cellular apical constriction. However, the cellular and molecular biomechanics of these processes are not understood. Here, using tissue-targeting techniques, we show that the myosin IIB motor protein complex is essential for both these processes, as well as for conferring resistance to deformation to the neural plate tissue. We show that myosin IIB is required for actin-cytoskeletal organization in both superficial and deep layers of the Xenopus neural plate. In the superficial layer, myosin IIB is needed for apical actin accumulation, which underlies constriction of the neuroepithelial cells, and that ultimately drive neural plate bending, whereas in the deep neural cells myosin IIB organizes a cortical actin cytoskeleton, which we describe for the first time, and that is necessary for both normal neural cell cortical tension and shape and for autonomous CE of the neural tissue. We also show that myosin IIB is required for resistance to deformation ("stiffness") in the neural plate, indicating that the cytoskeleton-organizing roles of this protein translate in regulation of the biomechanical properties of the neural plate at the tissue-level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.