ArticleParasite immunology2009
Germinal centre and marginal zone B cells expand quickly in a second Plasmodium chabaudi malaria infection producing mature plasma cells.
Article in Parasite immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Analysis of human B-cell responses following ChAd63-MVA MSP1 and AMA1 immunization and controlled malaria infection.Immunology · 2014Trial
- Protocol for repeated Plasmodium chabaudi infection in a murine malaria model.STAR protocols · 2026Article
- Microbiome-mediated modulation of immune memory to P. yoelii affects the resistance to secondary cerebral malaria challenge.ImmunoHorizons · 2025Article
- Infection vs. Reinfection: The Immunomodulation of Erythropoiesis.International journal of molecular sciences · 2024Article
- Role of TAM Receptors in Antimalarial Humoral Immune Response.Pathogens (Basel, Switzerland) · 2024Review
- Current understanding of the immune potential of B-cell subsets in malarial pathogenesis.Frontiers in microbiology · 2023Review
- IgMParasitology · 2020Article
- Article
- Development of B Cell Memory in Malaria.Frontiers in immunology · 2019Review
- Humoral immune responses to infection: common mechanisms and unique strategies to combat pathogen immune evasion tactics.Current opinion in immunology · 2018Review
- To B or Not to B: Understanding B Cell Responses in the Development of Malaria Infection.Frontiers in immunology · 2018Review
- Immunogenicity of glycosylphosphatidylinositol-anchored micronemal antigen in natural Plasmodium vivax exposure.Malaria journal · 2017Article
- Turf wars: exploring splenomegaly in sickle cell disease in malaria-endemic regions.British journal of haematology · 2017Review
- Chronic Plasmodium chabaudi Infection Generates CD4 Memory T Cells with Increased T Cell Receptor Sensitivity but Poor Secondary Expansion and Increased Apoptosis.Infection and immunity · 2017Article
- Article
- Does EBV alter the pathogenesis of malaria?Parasite immunology · 2015Review
- Early effector cells survive the contraction phase in malaria infection and generate both central and effector memory T cells.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Recovery of an antiviral antibody response following attrition caused by unrelated infection.PLoS pathogens · 2014Article
- Long-lived Plasmodium falciparum specific memory B cells in naturally exposed Swedish travelers.European journal of immunology · 2013Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Antibodies and B cells are critical in the protective immune response to the blood stage of the malaria parasite, Plasmodium chabaudi. However, little is known about the development of memory B cells and their differentiation into plasma cells during infection or after re-infection. Here we have shown that B cells with phenotypic characteristics of memory cells (CD19(+)IgD(-) CD38(+), IgG1(+)) are generated in a primary Plasmodium chabaudi chabaudi infection of mice. In addition, we observed that germinal centre cells (CD19(+), GL7(+), MHCII(hi)) and Marginal Zone B cells (CD19(+)CD23(-)IgD(-)) show faster expansion on re-infection than in the primary, though other subsets do not. Interestingly, though both IgM(-) and IgM(+) memory cells are produced, IgM(+) memory cells do not expand on second infection. The second infection quickly produced mature bone marrow plasma cells (intracellular Ig(hi), CD138(hi), CD9(+), B220(-)), compared to primary infection; which generates a very large population of immature splenic plasma cells (B220+). This analysis suggests that a memory B cell population is generated after a single infection of malaria, which on re-infection responds quickly producing germinal centres and generating long-lived plasma cells making the second encounter with parasite more efficient.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.