ArticleJournal of cellular and molecular medicine2009
Dexamethasone inhibits lipopolysaccharide-induced hydrogen sulphide biosynthesis in intact cells and in an animal model of endotoxic shock.
Article in Journal of cellular and molecular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 61 citations in OpenAlex.
- Detection of exhaled hydrogen sulphide gas in healthy human volunteers during intravenous administration of sodium sulphide.British journal of clinical pharmacology · 2010Trial
- Crosstalk Between HHandbook of experimental pharmacology · 2026Review
- Corticosteroids in sepsis.Journal of intensive medicine · 2025Review
- Early-Life Hydrogen Sulfide Signaling as a Target for Cardiovascular-Kidney-Metabolic Syndrome Reprogramming.Antioxidants (Basel, Switzerland) · 2025Review
- Hydrogen Sulfide Expression May Affect Ovarian Cancer Progression and Drug Resistance.International journal of women's health · 2025Article
- Hydrogen Sulfide: A Versatile Molecule and Therapeutic Target in Health and Diseases.Biomolecules · 2024Review
- Bridging the Gap in Cancer Research: Sulfur Metabolism of Leukemic Cells with a Focus on L-Cysteine Metabolism and Hydrogen Sulfide-Producing Enzymes.Biomolecules · 2024Review
- The Impact of Drugs on Hydrogen Sulfide Homeostasis in Mammals.Antioxidants (Basel, Switzerland) · 2023Review
- Anti-Neuroinflammatory Potential of aAntioxidants (Basel, Switzerland) · 2023Article
- Effects of Early Initiation of High-Dose Dexamethasone Therapy on Pro-Inflammatory Cytokines and Mortality in LPS-Challenged Mice.Healthcare (Basel, Switzerland) · 2022Article
- Beneficial Effect of HInternational journal of molecular sciences · 2022Article
- Recent development of hydrogen sulfide-releasing biomaterials as novel therapies: a narrative review.Biomaterials translational · 2022Review
- Development of a physiomimetic model of acute respiratory distress syndrome by using ECM hydrogels and organ-on-a-chip devices.Frontiers in pharmacology · 2022Article
- Possible selection bias limits the interpretation of single-cell transcriptomics data of steroid-resistant asthma exacerbation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Comparative Effects of Dexamethasone and Meloxicam on Magnitude of the Acute Inflammatory Response Induced byJournal of inflammation research · 2020Article
- The impact of hydrocortisone treatment on neutrophil gelatinase-associated lipocalin release in porcine endotoxemic shock.Intensive care medicine experimental · 2017Article
- Advances in the Diagnosis of Sepsis: Hydrogen Sulfide as a Prognostic Marker of Septic Shock Severity.EJIFCC · 2017Article
- Anti-CD163-dexamethasone conjugate inhibits the acute phase response to lipopolysaccharide in rats.World journal of hepatology · 2016Article
- A cardioprotective insight of the cystathionine γ-lyase/hydrogen sulfide pathway.International journal of cardiology. Heart & vasculature · 2015Article
- H2S during circulatory shock: some unresolved questions.Nitric oxide : biology and chemistry · 2014Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dexamethasone (1 mg/kg, i.p.) administered either 1 hr before or 1 hr after E. coli lipopolysaccharide (LPS, 4 mg/kg, i.p.) in conscious rats inhibited the subsequent (4 hrs) rise in plasma cytokine (interleukin [IL]-1beta, tumour necrosis factor [TNF]-alpha), nitrate/nitrite (NO(x)), soluble intercellular adhesion molecule-1 (sICAM-1) concentration and lung/liver myeloperoxidase activity indicative of an anti-inflammatory effect. Dexamethasone also reduced the LPS-evoked rise in plasma hydrogen sulphide (H(2)S) concentration, liver H(2)S synthesizing activity and expression of cystathionine gamma lyase (CSE) and inducible nitric oxide synthase (iNOS). Mifepristone (RU-486) inhibited these effects. Dexamethasone (1-10 microM) reduced the LPS-evoked release of IL-1beta, TNF-alpha and L-selectin, decreased expression of CSE and iNOS and diminished nuclear factor kappaB (NF-kappaB)-DNA binding in isolated rat neutrophils. In contrast, NaHS (100 microM) increased L-selectin release from rat neutrophils. Dexamethasone also reduced LPS-induced up-regulation of CSE in foetal liver cells. 6-amino-4-(4-phenoxyphenylethylamino) quinazoline (QNZ, 10 nM), a selective inhibitor of transcription via the NF-kappaB pathway, abolished LPS-induced up-regulation of CSE expression. We propose that inhibition of CSE expression and reduction in formation of the pro-inflammatory component of H(2)S activity contributes to the anti-inflammatory effect of dexamethasone in endotoxic shock. Whether H(2)S plays a part in the anti-inflammatory effect of this steroid in other forms of inflammation such as arthritis or asthma warrants further study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.