ReviewImmunology2009
Review series on helminths, immune modulation and the hygiene hypothesis: mechanisms underlying helminth modulation of dendritic cell function.
Review in Immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Carbohydrates Metabolic Signatures in Immune Cells: Response to Infection.Frontiers in immunology · 2022Pooled it
- Emergent and Neglected Equine Filariosis in Egypt: Species Diversity and Host Immune Response.Pathogens (Basel, Switzerland) · 2022Article
- Article
- Revisiting the Mechanisms of Immune Evasion Employed by Human Parasites.Frontiers in cellular and infection microbiology · 2021Review
- BCG immunomodulation: From the 'hygiene hypothesis' to COVID-19.Immunobiology · 2021Review
- Cytokines and beyond: Regulation of innate immune responses during helminth infection.Cytokine · 2020Review
- Urinary suPAR: a non-invasive biomarker of infection and tissue inflammation for use in studies of large free-ranging mammals.Royal Society open science · 2020Article
- Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion.Immunity · 2017Article
- Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62.Scientific reports · 2017Article
- Article
- The dynamic changes of CD3eParasitology research · 2017Article
- Age, but not anthelmintic treatment, is associated with urinary neopterin levels in semi-free ranging Barbary macaques.Scientific reports · 2017Article
- Dendritic cells and parasites: from recognition and activation to immune response instruction.Seminars in immunopathology · 2017Review
- Identification of three immunodominant motifs with atypical isotype profile scattered over the Onchocerca volvulus proteome.PLoS neglected tropical diseases · 2017Article
- Recombinant Sj16 from Schistosoma japonicum contains a functional N-terminal nuclear localization signal necessary for nuclear translocation in dendritic cells and interleukin-10 production.Parasitology research · 2016Article
- Soil-transmitted helminth infections and leprosy: a cross-sectional study of the association between two major neglected tropical diseases in Indonesia.BMC infectious diseases · 2016Article
- Dendritic cell expression of the C-type lectin receptor CD209a: A novel innate parasite-sensing mechanism inducing Th17 cells that drive severe immunopathology in murine schistosome infection.Experimental parasitology · 2015Article
- Frequency of Blood-tissue Parasitic Infections in Patients with Multiple Sclerosis, as Compared to their Family Members.International journal of preventive medicine · 2014Article
- CD209a expression on dendritic cells is critical for the development of pathogenic Th17 cell responses in murine schistosomiasis.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Harnessing the helminth secretome for therapeutic immunomodulators.BioMed research international · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Dendritic cells (DCs) play a central role in activating CD4 T (T helper, Th) cells. As a component of their response to pathogen-associated stimuli, DCs produce cytokines and express surface molecules that provide important cues to modulate the effector functions of responding Th cells. Much is known of how DCs respond to, and influence immune response outcome to, bacterial and viral pathogens. However, relatively little is understood about how DCs respond to helminth parasites. This is an area of considerable interest since it impacts our understanding of the initiation of Th2 responses, which are stereotypically associated with helminth infections, and the regulation of allergic and autoimmune pathologies which evidence suggests are less severe or absent in individuals infected with helminths. This review attempts to summarize our understanding of the effects of helminth products on dendritic cell biology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.